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Tesis Doctoral
La regulación del transporte de L-arginina vía HCAT-1 por insulina involucra activación diferencial de los subtipos A y B de receptores de insulina y receptores de adenosina en células endoteliales de vena umbilical humana de diabetes gestacional
(2014-01-29)
Diabetes gestacional (DG) aumenta el transporte de L-arginina en la macrocirculación de la placenta. Insulina activa receptores de insulina (IRs) los cuales estimulan el transporte de Larginina via transportadores de ...
Artículo
Insulin Reverses D-Glucose–Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells
(Public Library of Science, 2015)
Vascular tone is controlled by the L-arginine/nitric oxide (NO) pathway, and NO bioavailability is strongly affected by hyperglycaemia-induced oxidative stress. Insulin leads to high expression and activity of human cationic ...
Artículo
Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes
(Frontiers Media, 2017)
Obesity is an important public health issue worldwide, where it is commonly associated with the development of metabolic disorders, especially insulin resistance (IR). Maternal obesity is associated with an increased risk ...
Artículo
Diseases of Pregnancy and Fetal Programming: Cell and Molecular Mechanisms
(Hindawi Publishing Corporation, 2014)
Artículo
Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature
(Nature Publishing Group, 2018)
Maternal physiological or supraphysiological hypercholesterolemia (MPH, MSPH) occurs during pregnancy. MSPH is associated with foetal endothelial dysfunction and atherosclerosis. However, the potential effects of MSPH on ...
Artículo
Nitric oxide and pH modulation in gynaecological cancer
(Wiley-Blackwell, 2016)
Nitric oxide plays several roles in cellular physiology, including control of the vascular tone and defence against pathogen infection. Neuronal, inducible and endothelial nitric oxide synthase (NOS) isoforms synthesize ...
Artículo
Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia
(Hindawi Publishing Corporation, 2015)
Maternal physiological hypercholesterolemia occurs during pregnancy, ensuring normal fetal development. In some cases, the maternal plasma cholesterol level increases to above this physiological range, leading to maternal ...
Artículo
Maternal insulin therapy does not restore foetoplacental endothelial dysfunction in gestational diabetes mellitus
(Elsevier, 2017)
Pregnant women diagnosed with gestational diabetes mellitus subjected to diet (GDMd) that do not reach normal glycaemia are passed to insulin therapy (GDMi). GDMd associates with increased human cationic amino acid transporter ...
Artículo
Nitric Oxide: A Regulator of Cellular Function in Health and Disease
(Hindawi Publishing Corporation, 2016)
Artículo
Exosomes derived from monocytes and from endothelial cells mediate monocyte and endothelial cell activation under high d-glucose conditions
(Elsevier, 2019)
Diabetes mellitus type 2 (DMT2) is characterized by hyperglycemia and associated with low grade inflammation affecting both endothelial cells and monocytes. Exosomes are nanovesicles, allow communication between endothelial ...