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Mostrando ítems 1-10 de 12
Artículo
Oxidative and Inflammatory Imbalance in Placenta and Kidney of sFlt1-Induced Early-Onset Preeclampsia Rat Model
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Preeclampsia (PE) is a pregnancy-specific disorder characterized by the new onset of hypertension plus proteinuria and/or end-organ dysfunction. Here, we investigate the role of the nicotinamide adenine dinucleotide phosphate ...
Artículo
Ophthalmic wild olive (acebuche) oil nanoemulsions exert oculoprotective effects against oxidative stress induced by arterial hypertension
(Elsevier, 2023)
Oxidative stress plays a key role in several systemic and ocular diseases, including hypertensive eye diseases. In this context, we previously showed that oral administration of wild olive (acebuche, ACE) oil from Olea ...
Artículo
Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm-Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive Mice
(Wiley, 2023)
Scope Our laboratory has previously described the antioxidant and anti-inflammatory potential of a wild olive (acebuche, ACE) oil against hypertension-associated vascular retinopathies. The current study aims to analyze ...
Artículo
Impact of maternal nutrition in viral infections during pregnancy
(Elsevier, 2021)
Other than being a physiological process, pregnancy is a condition characterized by major adaptations of maternal endocrine and metabolic homeostasis that are necessary to accommodate the fetoplacental unit. Unfortunately, ...
Patente. Invención
Uso del aceite de acebuchina en el daño retiniano asociado a la hipertensión arterial y patologías retinianas asociadas a la misma.
(Oficina Española de Patentes y Marcas (OEPM), 2022-12-12)
La presente invención pertenece al sector de la medicina y la nutrición, y busca paliar los problemas del daño retiniano asociado a la hipertensión arterial mediante la utilización del aceite de acebuchina, en la preparación ...
Artículo
Mechanism of vascular toxicity in rats subjected to treatment with a tyrosine kinase inhibitor
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Sunitinib (Su) is a tyrosine kinase inhibitor with antiangiogenic and antineoplastic effects that is recommended therapy for renal cell carcinoma, gastrointestinal stromal tumors, and pancreatic neuroendocrine tumors. ...
Artículo
Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension
(MDPI, 2020)
Oxidative stress plays an important role in the pathogenesis of ocular diseases, including hypertensive eye diseases. The beneficial effects of olive oil on cardiovascular diseases might rely on minor constituents. ...
Artículo
Hypertension secondary to nitric oxide depletion produces oxidative imbalance and inflammatory/fibrotic outcomes in the cornea of C57BL/6 mice.
(Springer, 2022)
Arterial hypertension (AH) leads to oxidative and infammatory imbalance that contribute to fbrosis development in many target organs. Here, we aimed to highlight the harmful efects of severe AH in the cornea. Our experimental ...
Artículo
Echinomycin mitigates ocular angiogenesis by transcriptional inhibition of the hypoxia-inducible factor-1
(Elsevier, 2021)
Background: Echinomycin (EKN), an inhibitor of hypoxia-inducible factor (HIF)-1 DNA-binding activity, has been implied as a possible therapeutic agent in ischemic diseases. Here, we assess EKN in hypoxia-driven responses ...
Tesis Doctoral
Potential of wild olive (acebuche) oil as an ocular protective factor in vascular retinopathies associated with arterial hypertension
(2023-07-10)
Arterial hypertension (AH) contributes to the excessive production of reactive oxygen species (ROS) that promote hypertensive-mediated organ damage (HMOD) via different mechanisms, including inflammatory and profibrotic ...