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Artículo
An approach to prospective primary school teachers' concept of environment and biodiversity through their design of educational itineraries: Validation of an evaluation rubric
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
The aim of this work is to promote outdoor activities to bring students closer to the environment and the biodiversity of their surroundings. In this sense, educational itineraries are a very good educational resource that ...
Artículo
A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity
(Springer Nature, 2020)
Artículo
CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
(Springer Nature, 2021)
Proper chromosome segregation is essential to avoid aneuploidy, yet this process fails with increasing age in mammalian oocytes. Here we report a role for the scarcely described protein CENP-V in oocyte spindle formation ...
Artículo
Nutritional composition, ultrastructural characterization, and peptidome profile of antioxidant hemp protein hydrolysates
(Elsevier, 2023)
Hemp is the term commonly used to refer to the variety of Cannabis sativa L. cultivated for industrial purposes. The seeds have gained interest in recent years as functional foods due to their nutritional composition and ...
Artículo
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy
(Nature Research, 2024-01-17)
ATTR amyloidosis is caused by the deposition of transthyretin in the form of amyloid fibrils in virtually every organ of the body, including the heart. This systemic deposition leads to a phenotypic variability that has ...
Artículo
RENEB Inter-Laboratory Comparison 2021: The Dicentric Chromosome Assay
(Radiation Research Society, 2023)
After large-scale radiation accidents where many individuals are suspected to be exposed to ionizing radiation, biological and physical retrospective dosimetry assays are important tools to aid clinical decision making by ...
Tesis Doctoral
Estudio de la familia de proteínas Rho GTPasas en la biología del neuroblastoma
(2022-07-14)
El neuroblastoma (NB) es el tumor extracraneal sólido de aparición más común durante la edad pediátrica. El NB surge a raíz de un desarrollo erróneo del linaje simpatoadrenal de la cresta neural. Es una enfermedad muy ...
Artículo
Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
(Springer Nature, 2021)
The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis is started near Aß plaques in ...
Artículo
Metabolic Disturbance of High-Saturated Fatty Acid Diet in Cognitive Preservation
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Aging continues to be the main cause of the development of Alzheimer’s, although it has been described that certain chronic inflammatory pathologies can negatively influence the progress of dementia, including obesity and ...
Artículo
EpiGraph: an open-source platform to quantify epithelial organization
(Oxford University Press, 2020)
Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational geometry and graph theory to measure the degree of order of any packed tissue. EpiGraph goes beyond ...