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Mostrando ítems 1-10 de 10
Artículo
EpiGraph: an open-source platform to quantify epithelial organization
(Oxford University Press, 2020)
Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational geometry and graph theory to measure the degree of order of any packed tissue. EpiGraph goes beyond ...
Artículo
Mechanics and self-organization in tissue development
(Elsevier, 2021)
Self-organization is an all-important feature of living systems that provides the means to achieve specialization and functionality at distinct spatio-temporal scales. Herein, we review this concept by addressing the packing ...
Artículo
The complex three-dimensional organization of epithelial tissues
(The Company of Biologists Ltd., 2021)
Understanding the cellular organization of tissues is key to developmental biology. In order to deal with this complex problem, researchers have taken advantage of reductionist approaches to reveal fundamental morphogenetic ...
Artículo
CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia
(Elsevier, 2023)
Decades of research have not yet fully explained the mechanisms of epithelial self-organization and 3D packing. Single-cell analysis of large 3D epithelial libraries is crucial for understanding the assembly and function ...
Tesis Doctoral
Estudio de la arquitectura epitelial en 3D, su variación natural y la aparición de patrones morfológicos a nivel celular
(2023-07-11)
Una de las cuestiones más fascinantes de la Biología del desarrollo es entender cómo los tejidos y órganos adquieren su forma, crítica para su función, en un proceso que se denomina morfogénesis. La fiel ejecución del ...
Tesis Doctoral
Scutoids unveil the three-dimensional packing in curved epithelia
(2020-07-16)
As animals develop, the initial simple planar epithelia of the early embryos must acquire complex three-dimensional architectures to form the final functional tissues of the organism. Epithelial bending is, therefore, a ...
Artículo
The topology of vitronectin: A complementary feature for neuroblastoma risk classification based on computer-aided detection
(Wiley, 2020)
Tumors are complex networks of constantly interacting elements: tumor cells, stromal cells, immune and stem cells, blood/lympathic vessels, nerve fibers and extracellular matrix components. These elements can influence ...
Tesis Doctoral
Topological analysis of the tumour microenvironment to study Neuroblastoma
(2020-09-03)
Solid tumours and their tumour microenvironment (TME) can be considered as complex networks whose elements are in constant physical stress. All the elements of the TME, including tumour cells, stromal cells, immune and ...
Artículo
Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales
(John Wiley and Sons Inc, 2023-03-29)
Surface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell membranes to single cells to tissues and organs. The relevance of surface curvature in biology is ...
Artículo
A quantitative principle to understand 3D cellular connectivity in epithelial tubes
(Cell Systems, 2022)
Apico-basal cell intercalations (scutoids) optimize packing and energy expenditure in curved epithelia. Further consequences of this new paradigm of tissue packing remain uncharacterized. In particular, how scutoids modify ...