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Tesis Doctoral
Estudio de la familia de proteínas Rho GTPasas en la biología del neuroblastoma
(2022-07-14)
El neuroblastoma (NB) es el tumor extracraneal sólido de aparición más común durante la edad pediátrica. El NB surge a raíz de un desarrollo erróneo del linaje simpatoadrenal de la cresta neural. Es una enfermedad muy ...
Artículo
The topology of vitronectin: A complementary feature for neuroblastoma risk classification based on computer-aided detection
(Wiley, 2020)
Tumors are complex networks of constantly interacting elements: tumor cells, stromal cells, immune and stem cells, blood/lympathic vessels, nerve fibers and extracellular matrix components. These elements can influence ...
Artículo
Biotensegrity of the Extracellular Matrix: Physiology, Dynamic Mechanical Balance, and Implications in Oncology and Mechanotherapy
(Frontiers Media, 2014)
Cells have the capacity to convert mechanical stimuli into chemical changes. This process is based on the tensegrity principle, a mechanism of tensional integrity. To date, this principle has been demonstrated to act in ...
Artículo
Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
(MDPI, 2020)
Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system ...