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Artículo
Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside
(Wiley, 2018)
Several clinically useful anticancer drugs selectively kill cancer cells by inducing DNA damage; the genomic instability and DNA repair defects of cancer cells make them more vulnerable than normal cells to the cytotoxicity ...
Artículo
Chromosomal Instability in Genome Evolution: From Cancer to Macroevolution
(MDPI, 2023)
The integrity of the genome is crucial for the survival of all living organisms. However, genomes need to adapt to survive certain pressures, and for this purpose use several mechanisms to diversify. Chromosomal instability ...
Artículo
Biotensegrity of the Extracellular Matrix: Physiology, Dynamic Mechanical Balance, and Implications in Oncology and Mechanotherapy
(Frontiers Media, 2014)
Cells have the capacity to convert mechanical stimuli into chemical changes. This process is based on the tensegrity principle, a mechanism of tensional integrity. To date, this principle has been demonstrated to act in ...
Artículo
Effect of DNA repair deficiencies on the cytotoxicity of resveratrol
(2015)
Numerous preclinical studies have shown that the naturally-occurring polyphenol resveratrol may produce health-beneficial effects in a variety of disorders, including cancer, diabetes, Alzheimer, and cardiovascular ...