Buscar
Mostrando ítems 1-6 de 6
Artículo
sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
(Taylor & Francis, 2022)
The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below 10% of normal, due to mutations that destabilise the native folded form of the enzyme and impair its ...
Artículo
Mixed monolayer of a nucleolipid and a phospholipid has improved properties for spectroelectrochemical sensing of complementary nucleobases
(Elsevier, 2021)
A mixed monolayer of 1,2-dipalmitoyl-sn-glycero-3-(cytidine diphosphate) nucleolipid (DG-CDP) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) was transferred from the air–water interface onto an gold (1 1 1) electrode ...
Artículo
Multi-objective integration of timetables, vehicle schedules and user routings in a transit network
(Elsevier, 2017)
The Transit Network Timetabling and Scheduling Problem (TNTSP) aims at determining anoptimal timetable for each line of a transit network by establishing departure and arrivaltimes at each station and allocating a vehicle ...
Artículo
Electrostatics affects formation of Watson-Crick complex between DNA bases in monolayers of nucleolipids deposited at a gold electrode surface
(Elsevier, 2021)
Chronocoulometry was applied to determine charge in a monolayer of nucleolipid (1,2-dipalmitoyl-sn‑glycero-3-(cytidine diphosphate)) deposited at a gold electrode surface. The immersion method was used to measure the ...
Artículo
Planning Rapid Transit Networks
(Elsevier, 2011)
Rapid transit construction projects are major endeavours that require long-term planning by several players, including politicians, urban planners, engineers, management consultants, and citizen groups. Traditionally, ...
Artículo
Closed-form expressions for computing flexoelectric coefficients in textured polycrystalline dielectrics
(Elsevier, 2024-01)
The volume average of the constituting properties of a textured polycrystalline aggregate (the Voigt average) provides a simple way to estimate the effective properties of such an aggregate in terms of its crystallographic ...