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Browsing by Author "Docobo Pérez, Fernando"
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Article
Amikacin Combined with Fosfomycin for Treatment of Neonatal Sepsis in the Setting of Highly Prevalent Antimicrobial Resistance
Darlow, Christopher A.; Docobo Pérez, Fernando; Farrington, Nicola; Johnson, Adam; McEntee, Laura; Unsworth, Jennifer; Hope, William (American Society for Microbiology, 2021-06-17)Antimicrobial resistance (particularly through extended-spectrum β-lactamase and aminoglycoside-modifying enzyme production) ...
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PhD Thesis
Bases moleculares de la resistencia a fosfomicina e implicación de las subpoblaciones con sensibilidad disminuida en su actividad in vitro.
Ballestero Téllez, Mónica (2018-01-18)El interés global que existe actualmente, en recuperar antibióticos antiguos para el tratamiento de infecciones causadas ...
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Article
Detection of low-level fosfomycin-resistant variants by decreasing glucose-6-phosphate concentration in fosfomycin susceptibility determination
Martín Gutiérrez, Guillermo; Docobo Pérez, Fernando; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro; Blázquez, Jesús; Rodríguez Beltrán, Jerónimo (Multidisciplinary Digital Publishing Institute (MDPI), 2020)Mutations that confer low-level fosfomycin resistance (LLFR) but not clinical resistance in Escherichia coli are increasingly ...
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Article
Disbalancing Envelope Stress Responses as a Strategy for Sensitization of Escherichia coli to Antimicrobial Agents
Recacha Villamor, Esther; Fox, Valeria; Díaz Díaz, Sara; García Duque, Ana; Docobo Pérez, Fernando; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (Frontiers Media, 2021)Disbalancing envelope stress responses was investigated as a strategy for sensitization of Escherichia coli to antimicrobial ...
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Article
Effect of Glycerol on Fosfomycin Activity against Escherichia coli
Ortiz Padilla, Miriam; Portillo Calderón, Inés María; Velázquez Escudero, Ana; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel; Docobo Pérez, Fernando (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels ...
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Article
Effect of RecA inactivation and detoxification systems on the evolution of ciprofloxacin resistance in Escherichia coli
Díaz Díaz, S.; Recacha Villamor, Esther; García Duque, A.; Docobo Pérez, Fernando; Blázquez, J. (Oxford University Press, 2022)Background Suppression of SOS response and overproduction of reactive oxygen species (ROS) through detoxification system ...
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PhD Thesis
Heterorresistencia a fosfomicina en Escherichia coli: bases moleculares y efecto en su potencial terapéutico
Portillo Calderón, Inés María (2022-03-15)En las últimas décadas, el aumento progresivo de la resistencia a los antimicrobianos se ha convertido en un problema ...
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Article
Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii
López-Rojas, Rafael; Domínguez-Herrera, J.; Mcconnell, Michael; Docobo Pérez, Fernando; Smani, Younes; Pachón Díaz, Jerónimo (Oxford University Press, 2011-01-07)Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in ...
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Article
Inoculum Effect on the Efficacies of Amoxicillin-Clavulanate, Piperacillin-Tazobactam, and Imipenem against Extended-Spectrum -Lactamase (ESBL)-Producing and Non-ESBL-Producing Escherichia coli in an Experimental Murine Sepsis Model
Docobo Pérez, Fernando; López Cerero, Lorena; López-Rojas, Rafael; Egea, P.; Domínguez-Herrera, J.; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Pachón Díaz, Jerónimo (American Society for Microbiology, 2013-04)Escherichia coli is commonly involved in infections with a heavy bacterial burden. Piperacillin-tazobactam and carbapenems ...
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Article
Interplay Among Different Fosfomycin Resistance Mechanisms in Klebsiella Pneumoniae
Ortiz Padilla, M.; Portillo Calderón, I.; De Gregorio Iaria, Belén; Blázquez, J.; Rodríguez Baño, Jesús; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel; Docobo Pérez, Fernando (American Society for Microbiology, 2021)The objectives of this study were to characterize the role of the uhpT, glpT, and fosA genes in fosfomycin resistance in ...
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PhD Thesis
Optimisation of the therapeutic potential of fosfomycin against Enterobacteriaceae: characterisation of genetic and physiological factors related to resistance and antimicrobial activity
Ortiz Padilla, Miriam (2023-05-30)Since the discovery of the first antimicrobials, bacteria with resistance mechanisms against them have been detected. The ...
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Article
Penicillin-Binding Protein Occupancy Dataset for 18 b-Lactams and 4 b-Lactamase Inhibitors in Neisseria gonorrhoeae
López Argüello, Silvia; Montaner, Maria; Mármol Salvador, Amanda; Velázquez Escudero, Ana; Docobo Pérez, Fernando; Oliver, Antonio; Moya, Bartolomé (American Society for Microbiology, 2023)The lack of effective first-line antibiotic treatments against Neisseria gonorrhoeae, and the worldwide dissemination of ...
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Article
Pharmacodynamics of fosfomycin: Insights into clinical use for antimicrobial resistance
Rodríguez Martínez, José Manuel; Conejo Gonzalo, Mª Carmen; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Docobo Pérez, Fernando (American Society for Microbiology, 2015-09-01)The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin ...
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Article
Platelet-activating Factor Receptor Initiates Contact of Acinetobacter baumannii Expressing Phosphorylcholine with Host Cells
Smani, Younes; Docobo Pérez, Fernando; López Rojas, Rafael; Domínguez Herrera, Juan; Ibáñez Martínez, José; Pachón Díaz, Jerónimo (2012-06)Adhesion is an initial and important step in Acinetobacter baumannii causing infections. However, the exact molecular ...
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Article
Population pharmacokinetics and pharmacodynamics of fosfomycin in non-critically ill patients with bacteremic urinary infection caused by multidrug-resistant Escherichia coli
Merino Bohórquez, Vicente; Docobo Pérez, Fernando; Sojo Dorado, Jesús; Morales, Isabel; Lupión Mendoza, Carmen; Martín, D.; Pascual Hernández, Álvaro; Rodríguez Baño, Jesús (Elsevier, 2018)Objectives: To describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection ...
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Presentation
Population pharmacokinetics of colistin: implications for clinical use for Gram-negative pathogens
Pachón Ibáñez, María Eugenia; Docobo Pérez, Fernando; Blanquero Bravo, Rafael; Garnacho Montero, José; Benítez Peña, Sandra; Dimopoulos, George; Rosso Fernández, Clara; Gutiérrez Pizarraya, Antonio; López Cortés, Luis Fernando; Cisneros Herreros, José Miguel (2016)The objective of this study was to characterize the pharmacokinetics of colistin methanesulphonate (CMS) and colistin in ...
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Article
Population pharmacokinetics of piperacillin in non-critically ill patients with bacteremia caused by enterobacteriaceae
Merino Bohórquez, Vicente; Docobo Pérez, Fernando; Valiente-Méndez, Adoración; Delgado-Valverde, Mercedes; Cameán, Manuel; Hope, William W.; Rodríguez-Baño, Jesús (MDPI, 2021-03-25)This study analyzes the pharmacokinetic variability of piperacillin in non-critically ill patients with Enterobacteriaceae ...
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Article
Quinolone Resistance Reversion by Targeting the SOS Response
Recacha, E.; Machuca, J.; Díaz Alba, P.; Docobo Pérez, Fernando; Rodríguez Beltrán, Jerónimo; Rodríguez Martínez, José Manuel (American Society for Microbiology, 2017)Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We ...
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Article
Synergistic Quinolone Sensitization by Targeting the recA SOS Response Gene and Oxidative Stress
Recacha, E.; Machuca, J.; García Duque, A.; Docobo Pérez, Fernando; Blázquez, J.; Díaz Díaz, S.; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (American Society for Microbiology, 2021-03-18)Suppression of the recA SOS response gene and reactive oxygen species (ROS) overproduction have been shown, separately, ...
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PhD Thesis
Tratamientos de la neumonía experimental por Staphylococcus aureus : estudios de eficacia terapéutica de cotrimoxazol, cloxacilina, linezolid y vancomicina frente a cepas S. aureus sensible y resistente a meticilina
Docobo Pérez, Fernando (2009)El objetivo general de este proyecto es comparar la actividad de cotrimoxazol, vancomicina, linezolid y cloxacilina ...