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Browsing by Author "Carrillo Jiménez, Alejandro"
Now showing items 1-8 of 8
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Article
Caspase-8 inhibition represses initial human monocyte activation in septic shock model
Oliva Martín, María José; Sánchez Abarca, Luis Ignacio; Rodhe, Johanna; Carrillo Jiménez, Alejandro; Vlachos, Pinelopi; Herrera Carmona, Antonio José; García Quintanilla, Alberto; Caballero Velázquez, Teresa; Venero Recio, José Luis (Impact Journals, 2016)In septic patients, the onset of septic shock occurs due to the over-activation of monocytes. We tested the therapeutic ...
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Article
Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model
Kavanagh, Edel T.; Burguillos García, Miguel Ángel; Carrillo Jiménez, Alejandro; Oliva Martín, María José; Santiago Pavón, Martiniano; Rodhe, Johanna; Joseph, Bertrand; Venero Recio, José Luis (Impact Journals, LLC, 2015)Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative ...
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Article
Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation
Carrillo Jiménez, Alejandro; Puigdellívol, Mar; Vilalta, Anna; Venero Recio, José Luis; Brown, Charles Guy; Burguillos García, Miguel Ángel (Frontiers Media, 2018)Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, ...
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Article
Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration
Kei Yip, Ping; Carrillo Jiménez, Alejandro; King, Paul; Vilalta, Anna; Venero Recio, José Luis; Burguillos García, Miguel Ángel (Nature, 2017)Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an ...
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PhD Thesis
Papel de la galectina-3 en la respuesta inmune y en la pérdida neuronal asociada a un modelo murino de daño cerebral traumático.
Carrillo Jiménez, Alejandro (2018-07-13)La lesión cerebral traumática (TBI) es actualmente una causa importante de muerte y discapacidad en la sociedad occidental, ...
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Article
Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease
García Domínguez, Irene; Veselá, Karolina; García Revilla, Juan; Carrillo Jiménez, Alejandro; Roca Ceballos, María Angustias; Santiago Pavón, Martiniano; Martínez de Pablos, Rocío; Venero Recio, José Luis (Frontiers Media, 2018)The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role ...
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Article
Relevance of chronic stress and the two faces of microglia in Parkinson’s disease
Herrera Carmona, Antonio José; Espinosa Oliva, Ana María; Carrillo Jiménez, Alejandro; Oliva Martín, María José; García Revilla, Juan; García Quintanilla, Alberto; Martínez de Pablos, Rocío; Venero Recio, José Luis (rontiers Research Foundation, 2015)This review is aimed to highlight the importance of stress and glucocorticoids (GCs) in modulating the ...
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Article
TET2 Regulates the Neuroinflammatory Response in Microglia
Carrillo Jiménez, Alejandro; Ruiz Laza, Rocío; García Domínguez, Irene; García Revilla, Juan; Espinosa Oliva, Ana María; Venero Recio, José Luis; Burguillos García, Miguel Ángel; Tayara, Khadija (Elsevier, 2019)Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for ...