- idUS
- Listar por autor
Listar por autor "Walpole, Samuel"
Mostrando ítems 1-8 de 8
-
Artículo
Correction: Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design
Beekman, Andrew M.; Cominetti, Marco M. D.; Walpole, Samuel; Prabhu, Saurabh; O'Connell, Maria A.; Angulo Álvarez, Jesús; Searcey, Mark (Royal Society of Chemistry: Open Access, 2019) -
Artículo
Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B
Monaco, Serena; Walpole, Samuel; Doukani, Hassan; Nepravishta, Ridvan; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Ramos Soriano, Francisco Javier; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Wiley, 2020)Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ...
-
Artículo
Fucosidases from the human gut symbiont Ruminococcus gnavus
Wu, Haiyang; Rebello, Osmond; Owen, C. David; Walpole, Samuel; Bennati Granier, Chloe; Ndeh, Didier; Monaco, Serena; Angulo Álvarez, Jesús (Springer, 2021)The availability and repartition of fucosylated glycans within the gastrointestinal tract contributes to the adaptation ...
-
Artículo
Ginsenosides act as positive modulators of P2X4 receptors
Dhuna, K.; Felgate, M.; Bidula, S.M.; Walpole, Samuel; Bibic, L.; Cromer, B.A.; Angulo Álvarez, Jesús; Sanderson, J.; Stebbing, M.J.; Stokes, L. (American Society for Pharmacology and Experimental Therapeutics (ASPET), 2019)We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting as positive allosteric modulators ...
-
Artículo
Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design
Beekman, Andrew M.; Cominetti, Marco M. D.; Walpole, Samuel; Prabhu, Saurabh; O'Connell, Maria A.; Angulo Álvarez, Jesús; Searcey, Mark (Royal Society of Chemistry: Open Access, 2019)The development of protein–protein interaction (PPI) inhibitors with therapeutic value is of increasing importance as the ...
-
Artículo
Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7
Bidula, S.M.; Cromer, B.A.; Walpole, Samuel; Angulo Álvarez, Jesús; Stokes, Leanne (Nature Research (part of Springer Nature): Fully open access journals, 2019)P2X7 receptors are important in the regulation of inflammatory responses and immune responses to intracellular pathogens ...
-
Artículo
Speeding-up the Determination of Protein-Ligand Affinities by STD NMR: The Reduced Data Set STD NMR Approach (rd-STD NMR)
Rocha, Gabriel; Ramírez Cárdenas, Jonathan; Padilla Pérez, María del Carmen; Walpole, Samuel; Nepravishta, Ridvan; García Moreno, M. Isabel; Sánchez Fernández, Elena Matilde; Ortiz Mellet, Carmen; Angulo, Jesús; Muñoz García, Juan Carlos (American Chemical Society, 2024-01-02)STD NMR spectroscopy is a powerful ligand-observed NMR tool for screening and characterizing the interactions of small ...
-
Artículo
The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract
Wu, H.; Crost, E.; Owen, C. David; van Bakel, W.; Martínez Gascuena, A.; Latousakis, Dimitrios; Hicks, Thomas; Walpole, Samuel; Urbanowicz, Paulina A.; Angulo Álvarez, Jesús; Juge, Nathalie (Public Library of Science, 2021)AU The:human Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly gut symbiont Ruminococcus gnavus displays strain-specific ...