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Listar por autor "Tomé, Mercedes"
Mostrando ítems 1-7 de 7
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Artículo
A Method for Unsupervised Semi-Quantification of Inmunohistochemical Staining with Beta Divergences
Sarmiento Vega, María Auxiliadora; Durán Díaz, Iván; Fondón García, Irene; Tomé, Mercedes; Bodineau, Clément; Durán, Raúl V. (MPDI, 2022-02)In many research laboratories, it is essential to determine the relative expression levels of some proteins of interest ...
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A Robust Method for the Unsupervised Scoring of Immunohistochemical Staining
Durán Díaz, Iván; Sarmiento Vega, María Auxiliadora; Fondón García, Irene; Bodineau, Clément; Tomé, Mercedes; Durán, Raúl V. (MDPI, 2024-02)Immunohistochemistry is a powerful technique that is widely used in biomedical research and clinics; it allows one to ...
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Artículo
Downregulation of Glutamine Synthetase, notglutaminolysis, is responsible for glutamine addiction inNotch1-driven acute lymphoblastic leukemia
Nguyen, Tra Ly; Nokin, Marie Julie; Terés, Silvia; Tomé, Mercedes; Bodineau, Clément; Galmar, Oriane; Murdoch, Piedad del Socorro; Durán Díaz, Raúl V. (Wiley, 2021)The cellular receptor Notch1 is a central regulator of T-cell development, and as a consequence, Notch1 pathway appears ...
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Glutamine, MTOR and autophagy: a multiconnection relationship
Bodineau, Clément; Tomé, Mercedes; Murdoch, Piedad del Socorro; Durán, Raúl V. (Taylor & Francis, 2022)Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 ...
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Manganese is a physiologically relevant TORC1 activator in yeast and mammals
Nicastro, Raffaele; Gaillard, Hélène; Zarzuela, Laura; Peli-Gulli, Marie-Pierre; Fernández García, Elisabet; Tomé, Mercedes; García Rodríguez, Néstor; Durán, Raúl V.; De Virgilio, Claudio; Wellinger, Ralf Erik (eLife Sciences Publications, 2022)The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are crucial for the prevention of human ...
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N7-methylguanosine methylation of tRNAs regulates survival to stress in cancer
García Vílchez, Raquel; Añazco Guenkova, Ana M.; López, Judith; Dietmann, Sabine; Tomé, Mercedes; Jimeno González, Sonia; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Huertas Sánchez, Pablo; Blanco, Sandra (Springer Nature, 2023)Tumour progression and therapy tolerance are highly regulated and complex processes largely dependent on the plasticity ...
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Artículo
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
Bodineau, Clément; Tomé, Mercedes; Murdoch, Piedad del Socorro; Courtois, Sarah; Durán Díaz, Raúl V.; Sciacovelli, Marco (Nature Research, 2021)Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and ...