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Listar por autor "Pivonka, Peter"
Mostrando ítems 1-8 de 8
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Artículo
A novel algorithm to resolve lack of convergence and checkerboard instability in bone adaptation simulations using non-local averaging
Calvo Gallego, José Luis; Pivonka, Peter; García Aznar, José Manuel; Martínez Reina, Francisco Javier (Wiley-Blackwell, 2021)Checkerboard is a typical instability in finite element (FE) simulations of bone adaptation and topology optimization in ...
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An in silico approach to elucidate the pathways leading to primary osteoporosis: age‑related vs. postmenopausal
Ruiz Lozano, Rocío; Calvo Gallego, José Luis; Pivonka, Peter; McDonald, Michele M.; Martínez Reina, Francisco Javier (Springer, 2024)Numerical models of bone remodelling have traditionally been used to perform in silico tests of bone loss in postmenopausal ...
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Are drug holidays a safe option in treatment of osteoporosis? — Insights from an in silico mechanistic PK–PD model of denosumab treatment of postmenopausal osteoporosis
Martínez Reina, Francisco Javier; Calvo Gallego, José Luis; Pivonka, Peter (Elsevier, 2021-01)Recent reviews by the clinical bone research community suggest caution with prescription of drug holidays for patients ...
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Assessment of Strategies for Safe Drug Discontinuation and Transition of Denosumab Treatment in PMO—Insights From a Mechanistic PK/PD Model of Bone Turnover
Martínez Reina, Francisco Javier; Calvo Gallego, José Luis; Martin, Madge; Pivonka, Peter (Frontiers Media S.A., 2022-06)Denosumab (Dmab) treatment against postmenopausal osteoporosis (PMO) has proven very efficient in increasing bone mineral ...
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Editorial: Bone integrity in patients with osteoporosis: Evaluation of fracture risk and influence of pharmacological treatments and mechanical aspects
Martínez Reina, Francisco Javier; Pivonka, Peter; Hambli, Ridha (Frontiers Research Foundation, 2023) -
Artículo
Effects of long-term treatment of denosumab on bone mineral density: insights from an in-silico model of bone mineralization
Martínez Reina, Francisco Javier; Pivonka, Peter (Elsevier, 2019)Denosumab is one of the most commonly prescribed anti-resorptive drugs for the treatment of postmenopausal osteoporosis. ...
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Mechanistic PK-PD model of alendronate treatment of postmenopausal osteoporosis predicts bone site-specific response
Calvo Gallego, José Luis; Pivonka, Peter; Ruiz Lozano, Rocío; Martínez Reina, Francisco Javier (Frontiers Media S.A., 2022-08-17)Alendronate is the most widely used drug for postmenopausal osteoporosis (PMO). It inhibits bone resorption, affecting ...
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Spatio-temporal simulations of bone remodelling using a bone cell population model based on cell availability
Calvo Gallego, José Luis; Manchado Morales, Pablo; Pivonka, Peter; Martínez Reina, Francisco Javier (Frontiers, 2023)Here we developed a spatio-temporal bone remodeling model to simulate the action of Basic Multicelluar Units (BMUs). This ...