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Mostrando ítems 1-6 de 6
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Clinical benefit of glasdegib plus low-dose cytarabine in patients with de novo and secondary acute myeloid leukemia: long-term analysis of a phase II randomized trial
Heuser, Michael; Smith, B. Douglas; Fiedler, Walter; Sekeres, Mikkael A.; Montesinos, Pau; Leber, Brian; Pérez Simón, José Antonio; Cortes, Jorge E. (Springer, 2021)This analysis from the phase II BRIGHT AML 1003 trial reports the long-term efficacy and safety of glasdegib + ...
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First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia
Salamero, Olga; Montesinos, Pau; Willekens, Christophe; Pérez Simón, José Antonio; Pigneux, Arnaud; Récher, Christian; Somervaille, Tim C.P. (American Society of Clinical Oncology, 2020)PURPOSE Iadademstat is a novel, highly potent, and selective inhibitor of LSD1 (KDM1A), with preclinical in vitro and ...
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Impact of FLT3–ITD mutation status and its ratio in a cohort of 2901 patients undergoing upfront intensive chemotherapy: a PETHEMA registry study
Ayala, Rosa; Carreño-Tarragona, Gonzalo; Barragán, Eva; Boluda, Blanca; Larráyoz, María J.; Chillón, María Carmen; Pérez Simón, José Antonio; Montesinos, Pau (MDPI, 2022-11-22)FLT3–ITD results in a poor prognosis in terms of overall survival (OS) and relapse-free survival (RFS) in acute myeloid ...
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Long-Term Outcomes After Autologous Versus Allogeneic Stem Cell Transplantation in Molecularly-Stratified Patients With Intermediate Cytogenetic Risk Acute Myeloid Leukemia: A PETHEMA Study.
Rodríguez-Arbolí, Eduardo; Martínez-Cuadrón, David; Rodríguez-Veiga, Rebeca; Carrillo-Cruz, Estrella; Gil-Cortés, Cristina; Serrano-López, Josefina; Pérez Simón, José Antonio; Montesinos, Pau (Elsevier, 2021)Acute myeloid leukemia (AML) with intermediate risk cytogenetics (IRcyto) comprises a variety of biological enti- ties ...
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Molecular landscape and validation of new genomic classification in 2668 adult AML patients: real life data from the PETHEMA registry
Sargas, Claudia; Ayala, Rosa; Larráyoz, María José; Chillón, María Carmen; Carrillo-Cruz, Estrella; Bilbao-Sieyro, Cristina; Pérez Simón, José Antonio; Montesinos, Pau (MDPI, 2023)Next–Generation Sequencing (NGS) implementation to perform accurate diagnosis in acute myeloid leukemia (AML) represents ...
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Networking for advanced molecular diagnosis in acute myeloid leukemia patients is possible: the PETHEMA NGS-AML project
Sargas, Claudia; Ayala, Rosa; Chillón, María del Carmen; Larráyoz, María J.; Carrillo-Cruz, Estrella; Bilbao, Cristina; Pérez Simón, José Antonio; Montesinos, Pau (Ferrata Storti Foundation, 2021-12)Next-generation sequencing (NGS) has recently been introduced to efficiently and simultaneously detect genetic variations ...