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Listar por autor "Khiar, Noureddine"
Mostrando ítems 1-20 de 34
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Artículo
An Efficient and Practical Method for the Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols
Borrego Sánchez de la Cuesta, Lorenzo Gabriel; Recio Jiménez, Rocío; Alcarranza Saucedo, Manuel; Khiar, Noureddine; Fernández Fernández, Inmaculada (Wiley Online Library, 2018-03)An efficient sulfinamide/olefin based chiral ligand, MetSulfolefin, has been developed for the enantioselective rhodium-catalysed ...
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Artículo
Biological Evaluation of Carbohydrate-based Aprepitant Analogs for Neuroblastoma Treatment
Valdivia Giménez, Victoria Esther; Recio Jiménez, Rocío; Lerena, Patricia; Pozo, Esther; Serrano, Rosario; Calero, Raúl; Pintado, Cristina; Pernia Leal, Manuel; Moreno Rodríguez, Nazaret; Organero, Juan Ángel; Khiar, Noureddine; Fernández Fernández, Inmaculada (Elsevier, 2024)Different studies using Aprepitant, a NK1R antagonist currently used as a clinical drug for treating chemotherapy-related ...
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Artículo
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity
Recio Jiménez, Rocío; Lerena Pérez, Patricia; Pozo Torres, Esther; Calderón Montaño, José Manuel; Burgos Morón, Estefanía; López Lázaro, Miguel; Valdivia Giménez, Victoria Esther; Pernia Leal, Manuel; Mouillac, Bernard; Organero, Juan Ángel; Khiar, Noureddine; Fernández Fernández, Inmaculada (American Chemical Society, 2021)NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment ...
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Artículo
Chiral sulfur derivatives in the allylation of acyl hydrazones: C 2-symmetric bis-sulfinamides as enhanced chiral organic promoters
Fernández Fernández, Inmaculada; Alcudia Cruz, Ana; Gori, Beatrice; Valdivia Giménez, Victoria Esther; Recio Jiménez, Rocío; García, María Victoria; Khiar, Noureddine (Royal Society of Chemistry, 2010-10)Monosulfinamides and C2-symmetric bis-sulfinamides are convenient neutral chiral promoters in the allylation of acyl ...
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Artículo
Continuous flow synthesis of PCN-222 (MOF-545) with controlled size and morphology: a sustainable approach for efficient production
Zuliani, A; Castillejos Anguiano, María del Carmen; Khiar, Noureddine (Royal Society of Chemistry, 2023-11-21)Zirconium-based MOFs, such as PCN-222 (MOF-545), have gained attention due to their regular porosity, tuneable pore size, ...
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Tesis Doctoral
Derivados quirales de azufre y de fósforo: síntesis y aplicaciones en catálisis asimétrica
Chelouan, Ahmed (2014-12-19)El trabajo presentado en esta Tesis Doctoral forma parte de un proyecto de investigación más amplio desarrollado a lo largo ...
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Ponencia
Design and synthesis of supramolecular hydrogels for biomedical applications
Romero Ben, Elena; Valdivia Giménez, Victoria Esther; Khiar, Noureddine (Universidad Pablo de Olavide, 2016)Motivation: Only a few cells in the human organism keep their ability to regenerate. Hence, modern medical research intends ...
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Artículo
Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification
Recio Jiménez, Rocío; Vengut-Climent, Empar; Mouillac, Bernard; Orcel, Hélène; López Lázaro, Miguel; Calderón Montaño, José Manuel; Álvarez González, Eleuterio; Khiar, Noureddine; Fernández Fernández, Inmaculada (Elsevier, 2017)A library of 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyrans has been synthesized as a new family of non-peptide ...
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Artículo
Divergent approach to nanoscale glycomicelles and photo-responsive supramolecular glycogels. Implications for drug delivery and photoswitching lectin affinity
Romero Ben, Elena; Castillejos Anguiano, María del Carmen; Rosales Barrios, Cristian; Expósito, María; Ruda, Pilar; Castillo, Paula M.; Khiar, Noureddine (Royal Society of Chemistry, 2023-10-09)The field of stimuli-responsive supramolecular biomaterials has rapidly advanced in recent years, with potential applications ...
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Artículo
DMAP-Catalysed Sulfinylation of Diacetone-D-Glucose: Improved Method for the Synthesis of Enantiopure tert-Butyl Sulfoxides and tert-Butanesulfinamide
Chelouan, Ahmed; Recio Jiménez, Rocío; Alcudia Cruz, Ana; Khiar, Noureddine; Fernández Fernández, Inmaculada (Wiley Online Library, 2014-11)An improved method for the tert-butanesulfinylation of diacetone glucose with tert-butanesulfinyl chloride is reported. ...
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Artículo
Enantioselective synthesis of 4-amino-3,4-dihydrocoumarins and their non-cyclic hydroxyester precursors: Biological evaluation for the treatment of glioblastoma multiforme
Borrego Sánchez de la Cuesta, Lorenzo Gabriel; Recio Jiménez, Rocío; Moreno Rodríguez, Nazaret; Chelouan, Ahmed; Álvarez, Eleuterio; Sánchez Coronilla, Antonio; Caro Salazar, Carlos; Pearson, John R.; García-Martín, María Luisa; Khiar, Noureddine; Fernández Fernández, Inmaculada (Elsevier, 2022)The stereoselective addition of ethyl acetate enolate to the C═N bond of N-tert-butylsulfinylimines has been investigated ...
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Artículo
Enzyme-Responsive Zr-Based Metal-Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands
Carrillo Carrión, Carolina; Comaills, Valentine; Visiga, Ana M.; Gauthier, Benoit R.; Khiar, Noureddine (American Chemical Society, 2023)We report for the first time the controlled drug release from a nanoscale Zr-based metal-organic framework (MOF), UiO-66, ...
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Artículo
Improved non-covalent biofunctionalization of multi-walled carbon nanotubes using carbohydrate amphiphiles with a butterfly-like polyaromatic tail
Assali, Mohyeddin; Pernia Leal, Manuel; Fernández Fernández, Inmaculada; Romero Gómez, Pablo; Baati, Rachid; Khiar, Noureddine (Springer, 2010)We have developed an efficient strategy for the non-covalent functionalization of multi-walled carbon nanotubes (MWCNTs) ...
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Artículo
Molecular bottom-up approaches for the synthesis of inorganic and hybrid nanostructures
Escudero Belmonte, Alberto; Carrillo Carrión, Carolina; Romero Ben, Elena; Franco, Ana; Rosales Barrios, Christian; Castillejos Anguiano, María del Carmen; Khiar, Noureddine (Multidisciplinary Digital Publishing Institute (MDPI), 2021)Chemical routes for the synthesis of nanostructures are fundamental in nanoscience. Among the different strategies for the ...
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Artículo
N -Isopropylsulfinylimines vs. N-tert -butylsulfinylimines in the stereoselective synthesis of sterically hindered amines: An improved synthesis of enantiopure (R)- And (S)-rimantadine and the trifluoromethylated analogues
Moreno Rodríguez, Nazaret; Recio Jiménez, Rocío; Valdivia Giménez, Victoria Esther; Khiar, Noureddine; Fernández Fernández, Inmaculada (Royal Society of Chemistry, 2019-11-04)An improved fully stereoselective synthesis of both enantiomers of rimantadine and its trifluoromethylated analogues has ...
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Tesis Doctoral
Nanotubos de carbono biocampatibles, síntesis y aplicaciones en biomedicina
Assali, Mohyeddin (2012-01-01)Considerando todo lo comentado anteriormente, el planteamiento general de esta Tesis Doctoral ha consistido en la síntesis ...
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Artículo
New sulfur-phosphine ligands derived from sugars: synthesis and application in palladium-catalyzed allylic alkylation and in rhodium asymmetric hydrogenation
Khiar, Noureddine; Navas, Raquel; Álvarez González, Eleuterio; Fernández Fernández, Inmaculada (Arkat USA, 2008)An efficient route to mixed phosphine / thioglycoside ligands type IV starting from glucose pentaacetate is reported. In ...
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Artículo
NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins
Recio Jiménez, Rocío; Elhalem, Eleonora; Benito, Juan M.; Fernández Fernández, Inmaculada; Khiar, Noureddine (Elsevier, 2018)Sulforaphane (SFN), a phytochemical isolated from broccoli, is an important antitumoral compound with additional beneficial ...
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Tesis Doctoral
Nuevas aplicaciones de los derivados quirales de Azufre: Organocatálisis, síntesis enantioselectiva de calciomiméticos y acoplamiento de Suzuki - Miyaura
Valdivia Giménez, Victoria Esther (2010) -
Tesis Doctoral
Nuevas aproximaciones modulares para la síntesis estereoselectiva de ligandos quirales bidentados y compuestos de interés farmacológico, a partir de n-terc-butilsulfiniliminas.
Borrego Sánchez de la Cuesta, Lorenzo Gabriel (2017-11-24)