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Listar por autor "Herrera Moyano, Emilia"
Mostrando ítems 1-11 de 11
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A unified model for the molecular basis of Xeroderma pigmentosum-Cockayne Syndrome
Moriel Carretero, María; Herrera Moyano, Emilia; Aguilera López, Andrés (Taylor & Francis Open, 2015)Nucleotide Excision Repair (NER) is a pathway that removes lesions distorting the DNA helix. The molecular basis of the ...
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FANCD2 facilitates replication through common fragile sites
Madireddy, Advaitha; Aguilera López, Andrés; Herrera Moyano, Emilia; García Rubio, María Luisa; Owen, Nichole; Olson, Susan (Elsevier, 2016)Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the ...
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High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast
Andersen, Sabrina L.; Zhang, Aimee; Dominska, Margaret; Moriel Carretero, María; Herrera Moyano, Emilia; Aguilera López, Andrés (Public Library of Science, 2016)The Saccharomyces cerevisae RAD3 gene is the homolog of human XPD, an essential gene encoding a DNA helicase of the TFIIH ...
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Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
Gómez González, Belén; Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Aguilera López, Andrés (Taylor & Francis, 2020)A large body of research supports that transcription plays a major role among the many sources of replicative stress ...
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The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability
Tumini, Emanuela; Herrera Moyano, Emilia; San Martín Alonso, Marta; Barroso Ceballos, Sonia Inés; Galmarini, Carlos María; Aguilera López, Andrés (American Association for Cancer Research, 2019)R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...
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The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
Bayona Feliu, Aleix; Herrera Moyano, Emilia; Badra Fajardo, Nibal; Galván Femenía, Iván; Soler Oliva, María Eugenia; Aguilera López, Andrés (Nature Research, 2023)Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large ...
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The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins
Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Muñoz Sánchez, Sergio; García Rubio, María Luisa; Gómez González, Belén; Aguilera López, Andrés (EMBO Press, 2019-07-24)Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ...
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The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
García Rubio, María Luisa; Pérez Calero, Carmen; Barroso Ceballos, Sonia Inés; Tumini, Emanuela; Herrera Moyano, Emilia; Aguilera López, Andrés (Public Library of Science, 2015)Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have ...
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The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne Syndrome-like phenotypes
Herrera Moyano, Emilia; Moriel Carretero, María; Montelone, Beth A.; Aguilera López, Andrés (Public Library of Science, 2014)The eukaryotic TFIIH complex is involved in Nucleotide Excision Repair and transcription initiation. We analyzed three ...
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The Role of Replication-Associated Repair Factors on R-Loops
Bhatia, Vaibhav; Herrera Moyano, Emilia; Aguilera López, Andrés; Gómez González, Belén (MDPI, 2017)The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) ...
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The yeast and human FACT chromatin-reorganizing complexes resolve R-loop-mediated transcription-replication conflicts
Herrera Moyano, Emilia; Mergui, Xenia; García Rubio, María Luisa; Barroso Ceballos, Sonia Inés; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2014)FACT (facilitates chromatin transcription) is a chromatin-reorganizing complex that swaps nucleosomes around the RNA ...