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Listar por autor "Docobo Pérez, Fernando"
Mostrando ítems 1-20 de 27
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Artículo
Amikacin Combined with Fosfomycin for Treatment of Neonatal Sepsis in the Setting of Highly Prevalent Antimicrobial Resistance
Darlow, Christopher A.; Docobo Pérez, Fernando; Farrington, Nicola; Johnson, Adam; McEntee, Laura; Unsworth, Jennifer; Hope, William (American Society for Microbiology, 2021-06-17)Antimicrobial resistance (particularly through extended-spectrum β-lactamase and aminoglycoside-modifying enzyme production) ...
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Tesis Doctoral
Bases moleculares de la resistencia a fosfomicina e implicación de las subpoblaciones con sensibilidad disminuida en su actividad in vitro.
Ballestero Téllez, Mónica (2018-01-18)El interés global que existe actualmente, en recuperar antibióticos antiguos para el tratamiento de infecciones causadas ...
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Artículo
Contribution of hypermutation to fosfomycin heteroresistance in Escherichia coli
Portillo Calderón, Inés María; Ortiz Padilla, Miriam; Rodríguez Martínez, José Manuel; De Gregorio Iaria, Belén; Blázquez, Jesús; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Docobo Pérez, Fernando (Oxford University Press, 2020)Objectives: To explore the effect of combining defects in DNA repair systems with the presence of fosfomycin-resistant ...
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Artículo
Detection of low-level fosfomycin-resistant variants by decreasing glucose-6-phosphate concentration in fosfomycin susceptibility determination
Martín Gutiérrez, Guillermo; Docobo Pérez, Fernando; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro; Blázquez, Jesús; Rodríguez Beltrán, Jerónimo (Multidisciplinary Digital Publishing Institute (MDPI), 2020)Mutations that confer low-level fosfomycin resistance (LLFR) but not clinical resistance in Escherichia coli are increasingly ...
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Artículo
Disbalancing Envelope Stress Responses as a Strategy for Sensitization of Escherichia coli to Antimicrobial Agents
Recacha Villamor, Esther; Fox, Valeria; Díaz Díaz, Sara; García Duque, Ana; Docobo Pérez, Fernando; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (Frontiers Media, 2021)Disbalancing envelope stress responses was investigated as a strategy for sensitization of Escherichia coli to antimicrobial ...
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Artículo
Effect of Glycerol on Fosfomycin Activity against Escherichia coli
Ortiz Padilla, Miriam; Portillo Calderón, Inés María; Velázquez Escudero, Ana; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel; Docobo Pérez, Fernando (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels ...
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Artículo
Effect of RecA inactivation and detoxification systems on the evolution of ciprofloxacin resistance in Escherichia coli
Díaz Díaz, S.; Recacha Villamor, Esther; García Duque, A.; Docobo Pérez, Fernando; Blázquez, J. (Oxford University Press, 2022)Background Suppression of SOS response and overproduction of reactive oxygen species (ROS) through detoxification system ...
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Artículo
Effectiveness of fosfomycin trometamol as oral step-down therapy for bacteraemic urinary tract infections due to MDR Escherichia coli: a post hoc analysis of the FOREST randomized trial
Sojo-Dorado, Jesus; Lopez-Hernandez, Inmaculada; Hernandez-Torres, Alicia; Retamar Gentil, Pilar; Merino de Lucas, Esperanza; Escola-Verge, Laura; Docobo Pérez, Fernando; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Oxford Academic, 2023)Background Fosfomycin is a potentially attractive option as step-down therapy for bacteraemic urinary tract infections ...
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Artículo
Evaluation of temocillin efficacy against KPC-2-producing Klebsiella pneumoniae isolates in a hollow-fibre infection model
Rodríguez Ochoa, José Luis; Pérez Palacios, Patricia; Merino Bohórquez, Vicente; Ortiz Padilla, Miriam; Velázquez Escudero, Ana; Rodríguez-Baño, Jesús; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro; Docobo Pérez, Fernando (Oxford University Press, 2024-02-09)Background: Temocillin is an old antimicrobial that is resistant to hydrolysis by ESBLs but has variable activity against ...
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Artículo
Heterogeneity of SOS response expression in clinical isolates of Escherichia coli influences adaptation to antimicrobial stress
Díaz Díaz, Sara; García Montaner, Andrea; Vanni, Roberta; Murillo Torres, Marina; Recacha, Esther; Pulido, Marina R.; Romero Muñoz, María; Docobo Pérez, Fernando; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (Elsevier, 2024-04-23)In recent years, new evidence has shown that the SOS response plays an important role in the response to antimicrobials, ...
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Tesis Doctoral
Heterorresistencia a fosfomicina en Escherichia coli: bases moleculares y efecto en su potencial terapéutico
Portillo Calderón, Inés María (2022-03-15)En las últimas décadas, el aumento progresivo de la resistencia a los antimicrobianos se ha convertido en un problema ...
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Artículo
Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii
López-Rojas, Rafael; Domínguez-Herrera, J.; Mcconnell, Michael; Docobo Pérez, Fernando; Smani, Younes; Pachón Díaz, Jerónimo (Oxford University Press, 2011-01-07)Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in ...
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Artículo
Inoculum Effect on the Efficacies of Amoxicillin-Clavulanate, Piperacillin-Tazobactam, and Imipenem against Extended-Spectrum -Lactamase (ESBL)-Producing and Non-ESBL-Producing Escherichia coli in an Experimental Murine Sepsis Model
Docobo Pérez, Fernando; López Cerero, Lorena; López-Rojas, Rafael; Egea, P.; Domínguez-Herrera, J.; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Pachón Díaz, Jerónimo (American Society for Microbiology, 2013-04)Escherichia coli is commonly involved in infections with a heavy bacterial burden. Piperacillin-tazobactam and carbapenems ...
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Artículo
Interplay Among Different Fosfomycin Resistance Mechanisms in Klebsiella Pneumoniae
Ortiz Padilla, M.; Portillo Calderón, I.; De Gregorio Iaria, Belén; Blázquez, J.; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel; Docobo Pérez, Fernando (American Society for Microbiology, 2021)The objectives of this study were to characterize the role of the uhpT, glpT, and fosA genes in fosfomycin resistance in ...
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Tesis Doctoral
Optimisation of the therapeutic potential of fosfomycin against Enterobacteriaceae: characterisation of genetic and physiological factors related to resistance and antimicrobial activity
Ortiz Padilla, Miriam (2023-05-30)Since the discovery of the first antimicrobials, bacteria with resistance mechanisms against them have been detected. The ...
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Artículo
Penicillin-Binding Protein Occupancy Dataset for 18 b-Lactams and 4 b-Lactamase Inhibitors in Neisseria gonorrhoeae
López Argüello, Silvia; Montaner, Maria; Mármol Salvador, Amanda; Velázquez Escudero, Ana; Docobo Pérez, Fernando; Oliver, Antonio; Moya, Bartolomé (American Society for Microbiology, 2023)The lack of effective first-line antibiotic treatments against Neisseria gonorrhoeae, and the worldwide dissemination of ...
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Artículo
Pharmacodynamics of fosfomycin: Insights into clinical use for antimicrobial resistance
Rodríguez Martínez, José Manuel; Conejo Gonzalo, Mª Carmen; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Docobo Pérez, Fernando (American Society for Microbiology, 2015-09-01)The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin ...
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Artículo
Platelet-activating Factor Receptor Initiates Contact of Acinetobacter baumannii Expressing Phosphorylcholine with Host Cells
Smani, Younes; Docobo Pérez, Fernando; López Rojas, Rafael; Domínguez Herrera, Juan; Ibáñez Martínez, José; Pachón Díaz, Jerónimo (2012-06)Adhesion is an initial and important step in Acinetobacter baumannii causing infections. However, the exact molecular ...
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Artículo
Population pharmacokinetics and pharmacodynamics of fosfomycin in non-critically ill patients with bacteremic urinary infection caused by multidrug-resistant Escherichia coli
Merino Bohórquez, Vicente; Docobo Pérez, Fernando; Sojo Dorado, Jesús; Morales, Isabel; Lupión Mendoza, Carmen; Martín, D.; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Elsevier, 2018)Objectives: To describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection ...
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Ponencia
Population pharmacokinetics of colistin: implications for clinical use for Gram-negative pathogens
Pachón Ibáñez, María Eugenia; Docobo Pérez, Fernando; Blanquero Bravo, Rafael; Garnacho Montero, José; Benítez Peña, Sandra; Dimopoulos, George; Rosso Fernández, Clara; Gutiérrez Pizarraya, Antonio; López Cortés, Luis Fernando; Cisneros Herreros, José Miguel (2016)The objective of this study was to characterize the pharmacokinetics of colistin methanesulphonate (CMS) and colistin in ...