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Listar por autor "Álvarez Quilón, Alejandro"
Mostrando ítems 1-5 de 5
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Artículo
ATM specifically mediates repair of double-strand breaks with blocked DNA ends
Álvarez Quilón, Alejandro; Serrano Benítez, Almudena; Ariel Lieberman, Jenna; Quintero Ruiz, Maria Cristina; Sánchez Gutiérrez, Daniel; Escudero Cuadrado, Luis María; Cortés Ledesma, Felipe (Nature Publishing Group, 2014)Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative ...
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Artículo
Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency
Álvarez Quilón, Alejandro; Terrón Bautista, José; Delgado Sainz, Irene; Serrano Benítez, Almudena; Romero Granados, Rocío; Martínez García, Pedro Manuel; Jimeno González, Silvia; Bernal Lozano, Cristina; Quintero, Cristina; García Quintanilla, Lourdes; Cortés Ledesma, Felipe (Springer Nature, 2020)The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established ...
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Artículo
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
Caron, Pierre; Choudjaye, Jonathan; Clouaire, Thomas; Bugler, Béatrix; Daburon, Virginie; Aguirrebengoa, Marion; Álvarez Quilón, Alejandro; Cortés Ledesma, Felipe (Elsevier, 2015)DNA double-strand breaks (DSBs) elicit the so-called DNA damage response (DDR), largely relying on ataxia telangiectasia ...
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Tesis Doctoral
Role of ATM in the repair of blocked DNA double-strand breaks
Álvarez Quilón, Alejandro (2017-02-03)La Ataxia-telangiectasia (A-T) es un síndrome causado por mutaciones de pérdida de función en la quinasa ATM (Ataxia ...
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Artículo
TDP2-Dependent Non-Homologous End-Joining Protects against Topoisomerase II-Induced DNA Breaks and Genome Instability in Cells and In Vivo
Gómez Herreros, Fernando; Romero Granados, Rocío; Zeng, Zhihong; Álvarez Quilón, Alejandro; Quintero Ruiz, María Cristina; Ju, Limei; Umans, Lieve; Vemeire, Liesbeth; Huylebroeck, Danny; Caldecott, Keith W.; Cortés Ledesma, Felipe (Public Library of Science, 2013)Anticancer topoisomerase >poisons> exploit the break-and-rejoining mechanism of topoisomerase II (TOP2) to generate ...