Author profile: Toledo Aral, Juan José
Institutional data
| Name | Toledo Aral, Juan José |
| Department | Fisiología Médica y Biofísica |
| Knowledge area | Fisiología |
| Professional category | Catedrático de Universidad |
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Statistics
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No. publications
33
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No. visits
4820
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No. downloads
10219
| Publications |
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PhD Thesis
 Characterization of the nigrostriatal pathway in Parkinson's Disease mice models of overexpression of human alpha-synuclein and LRRK2 mutants
(2023)
Parkinson's disease (PD) is a long-term neurodegenerative disease with a complex array of symptoms and signs, involving ... |
Article
Protection and repair of the nigrostriatal pathway with stem-cell-derived carotid body glomus cell transplants in chronic MPTP Parkinsonian model
(MDPI, 2023)
Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of ... |
Article
Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate
(Nature Publishing Group, 2023)
Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective efficacy against infection in ... |
Article
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.
(CELL PRESS (Elsevier), 2022)
The autonomic nervous system is a master regulator of homeostatic processes and stress responses. Sym pathetic noradrenergic ... |
Article
Aquaporin-4 Mediates Permanent Brain Alterations in a Mouse Model of Hypoxia-Aged Hydrocephalus
(MDPI, 2021)
Aquaporin-4 (AQP4) is the principal water channel in the brain being expressed in astrocytes and ependymal cells. AQP4 ... |
Article
Is Carotid Body Infection Responsible for Silent Hypoxemia in COVID-19 Patients?
(Oxford University Press (OUP), 2021)
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Article
Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration
(Springer Nature, 2021)
A deeper understanding of early disease mechanisms occurring in Parkinson’s disease (PD) is needed to reveal restorative ... |
Article
Spanish Cell Therapy Network (TerCel): 15 years of successful collaborative translational research
(Elsevier, 2020)
In the current article we summarize the 15-year experience of the Spanish Cell Therapy Network (TerCel), a successful ... |
Article
AQP1 and AQP4 Contribution to Cerebrospinal Fluid Homeostasis
(MDPI, 2019)
Aquaporin 1 (AQP1), expressed in epithelial cells of the choroid plexus, and aquaporin 4 (AQP4) present in ependymal cells ... |
Article
Combined effects of aquaporin-4 and hypoxia produce age-related hydrocephalus
(Elsevier, 2018)
Aquaporin-4, present in ependymal cells, in glia limiting and abundantly in pericapillary astrocyte foot pro cesses, and ... |
Article
Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic parkinsonism model
(Wiley, 2018)
Neuroinflammation mediated by chronically activated microglia, largely caused by abnormal accumulation of misfolded ... |
Article
Long-term immunosuppression for CNS mouse xenotransplantation: Effects on nigrostriatal neurodegeneration and neuroprotective carotid body cell therapy
(Wiley, 2018)
Abstract Background: The use of long-term immunosuppressive treatments on neural trans plantation has been controversial ... |
PhD Thesis
Xenotrasplantes de cuerpo carotideo en ratones parkinsonianos inmunodeprimidos.
(2017)
Los trasplantes intraestriatales de cuerpo carotídeo (CC) han mostrado un claro efecto beneficioso en modelos animales de ... |
Article
Comparative analysis for the presence of IgG anti-aquaporin-1 in patients with NMO-Spectrum disorders
(MDPI AG, 2016)
Detection of IgG anti-Aquaporin-4 (AQP4) in serum of patients with Neuromyelitis optica syndrome disorders (NMOSD) has ... |
Article
Aquaporin-1 plays important role in proliferation by affecting cell cycle progression
(Wiley, 2016)
Aquaporin-1 (AQP1) has been associated with tumor development. Here, we investigated how AQP1 may affect cell proliferation. ... |
Article
Effects of Rho Kinase Inhibitors on Grafts of Dopaminergic Cell Precursors in a Rat Model of Parkinson's Disease.
(Wiley Online, 2016)
In models of Parkinson’s disease (PD), Rho kinase (ROCK) inhibitors have antiapoptotic and axonstabilizing effects on ... |
PhD Thesis
Desarrollo in vitro de nuevas terapias dirigidas con nanopartículas para el tratamiento del cáncer de tiroides
(2014)
A pesar de que la nanotecnología está siendo aplicada intensamente en la búsqueda de nuevos tratamientos para una amplia ... |
Patent
Procedimiento para detectar el precipitado de x-gal u otros precipitados opacos mediante microscopia confocal
(Oficina Española de Patentes y Marcas , 2013)
La presente solicitud de patente se refiere a un procedimiento para la obtención de imágenes confocales de la tinción ... |
| Article |
Chapter of Book
Carotid Body Transplants as a Therapy for Parkinson’s Disease
(The Royal Society of Chemistry, 2013)
Affecting over 1.5 million people across the world, Parkinson's disease is a progressive neurological condition characterized, ... |
Article
Overexpression of aquaporin-1 in lung adenocarcinomas and pleural mesotheliomas
(2011)
Aquaporin-1 (AQP1) is the main water channel responsible for water transport through many epithelia and endothelia. The ... |
Chapter of Book
Neuroprotection in Parkinson’s Disease
(Royal Society of Chemistry, 2011)
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Article
Functional and transcriptional induction of Aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1α
(2011)
Aquaporin-1 (AQP1) is a water channel that is highly expressed in tissues with rapid O2 transport. It has been reported ... |
PhD Thesis
Enfermedad de parkinson y síntomas urinarios: estudio clínico y en modelos animales
(2008)
Los pacientes con Enfermedad de Parkinson (EP) presentan un mayor porcentaje de síntomas urinarios e incontinencia que la ... |
PhD Thesis
GDNF y cuerpo carotídeo: implicaciones funcionales y uso en terapia celular
(2007)
El proyecto que se desarrolla en esta Tesis Doctoral se ha centrado en el estudio de los mecanismos celulares y moleculares ... |
PhD Thesis
 Quimiorrecepción del CO2 en la médula adrenal y facilitación de la permeabilidad a O2 por la acuaporina-1
(2007)
El desarrollo de esta Tesis se ha centrado en el estudio de los mecanismos celulares que permiten la quimiotransducción ... |
Article
Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression
(Elsevier, 2007)
O2 is essential for aerobic life, and the classic view is that it diffuses freely across the plasma membrane. However, ... |
Article
Rat Adrenal Chromaffin Cells Are Neonatal CO2 Sensors
(2005)
We studied the participation of adrenal medulla (AM) chromaffin cells in hypercapnic chemotransduction. Using amperometric ... |
Article
Selective Glial Cell Line-Derived Neurotrophic Factor Production in Adult Dopaminergic Carotid Body Cells In Situ and after Intrastriatal Transplantation
(2005)
Glial cell line-derived neurotrophic factor (GDNF) exerts a notable protective effect on dopaminergic neurons in rodent ... |
Article
Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats
(2003)
We studied the mechanisms underlying long-term functional recovery of hemiparkinsonian rats grafted intrastriatally with ... |
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Article
A Single Zinc Finger Motif in the Silencing Factor Rest Represses the Neural-Specific Type II Sodium Channel Promoter.
(PNAS, 1997)
The type II voltage-dependent sodium chan- nel is present in neuronal cells, where it mediates the ... |
Article
Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons
(1990)
The interaction of thyrotropin-releasing hormone (TRH) and its physiological metabolite TRH-OH with Na+ channels was studied ... |