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Artículo
Novel mixed-linkage β-glucan activated by c-di-GMP in Sinorhizobium meliloti
(National Academy of Sciences, 2015)
An artificial increase of cyclic diguanylate (c-di-GMP) levels in Sinorhizobium meliloti 8530, a bacterium that does not carry known cellulose synthesis genes, leads to overproduction of a substance that binds the dyes ...
Artículo
Isolation and identification of minor secoiridoids and phenolic components from thermally treated olive oil by-products
(Elsevier, 2015-11-15)
The application of an industrial process based on the hydrothermal treatment of 160 °C/60 min of alperujo, a by-product of olive oil extraction, allows the formation of a liquid phase containing a high concentration of ...
Artículo
Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
(Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2015)
The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported herein. Tetrava- lent and nonavalent dendrimers were obtained by means of the click chemistry approach ...
Artículo
Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: A structure-activity relationship study
(Royal Society of Chemistry, 2015)
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples of monodisperse gene delivery systems. The possibility to precisely control the architectural ...
Artículo
Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease
(Nature Publishing Group, 2015)
Gaucher disease (GD) is caused by mutations in the GBA1 gene, which encodes lysosomal β-glucocerebrosidase. Homozygosity for the L444P mutation in GBA1 is associated with high risk of neurological manifestations which are ...
Artículo
Strongly Emissive and Photostable Four-Coordinate Organoboron N,C Chelates and Their Use in Fluorescence Microscopy
(Wiley-Blackwell, 2015)
Six strongly fluorescent four-coordinate organoboron N,C chelates containing an aryl isoquinoline skeleton were prepared. Remarkably, the fluorescence quantum yields reach values of up to 0.74 in oxygen-free toluene. The ...
Artículo
Inhibition of Type 1 Fimbriae-mediated Escherichia Coli Adhesion and Biofilm Formation by Trimeric Cluster Thiomannosides Conjugated to Diamond Nanoparticles
(Royal Society of Chemistry, 2015)
Recent advances in nanotechnology have seen the development of a number of microbiocidal and/or anti-adhesive nanoparticles displaying activity against biofilms. In this work, trimeric thiomannoside clusters conjugated to ...
Artículo
Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors
(Royal Society of Chemistry, 2015)
2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic potential for the treatment of various diseases, including several lysosomal storage disorders. ...
Artículo
Synthesis of hyperpolarizable biomaterials at molecular level based on pyridinium-chitosan complexes
(Universidade Federal do Espírito Santo, 2015)
Potential NLO-phore materials based on chitosan are described for the first time in this study. A series of fluorescent and quaternized pyridinium– chitosan derivatives have been synthesized by reaction of this polymer ...
Artículo
Gold nanoparticles are suitable cores for building tunable iminosugar multivalency
(Royal Society of Chemistry: Open Access, 2015)
The first example of iminosugars multimerization based on gold nanoparticle cores was achieved by a straightforward synthetic strategy based on the use of simple glycosides of a-D-mannose or b-Dglucose to modulate the ...