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Mostrando ítems 11-20 de 36
Artículo
Total asymmetric synthesis of monosaccharides and analogues
(Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011)
Since the discovery of the 'formose reaction' by Butlerow,[1] total synthesis of carbohydrates has undergone rapid development. The most important methods for the asymmetric synthesis of monosaccharides and analogues of ...
Tesis Doctoral
Feniltio y fenilsulfinil glicósidos: síntesis de análogos de factoes Nod y de y de C-sulfocelobiosas
(1999)
La presente Tesis Doctoral se encuadra dentro de los proyectos de investigación sobre Isotiocianato, tioamnio- y sulfoaminoazúcares y Azaazúcares, nucleósidos y glicolípidos en los que viene trabajando nuestro grupo ...
Artículo
Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases
(Wiley-Blackwell, 2017)
Novel pyrrolidine-based multivalent iminosugars, synthesized by a CuAAC approach, have shown remarkable multivalent effects towards jack bean α-mannosidase and a Golgi α-mannosidase from Drosophila melanogaster, as well ...
Artículo
Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the clinical success of NAMPT inhibitors in cancer treatment. Previous studies found that high protein ...
Tesis Doctoral
Síntesis y reactividad de sistemas [2.2.1]bicíclicos. Estudio de la bioconjugación de proteínas con azanorbornadienos
(2020-05-24)
En esta Tesis Doctoral se presentan los resultados más relevantes obtenidos del estudio de reactividad llevado a cabo sobre sistemas [2.2.1]bicíclicos (7-heteronorbornanos y 7- heteronorbornadienos), así como su aplicación ...
Artículo
Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars
(Elsevier, 2019)
The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives and tri- or hexavalent alkynyl scaffolds is reported. The new multimeric compounds, together ...
Artículo
Azabicyclic vinyl sulfones for residue-specific dual protein labelling
(Royal Society of Chemistry, 2019)
We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective ...
Artículo
Synthesis of tri- and tetramines containing two 2,3-dihydroxypyrrolidine moieties and their inhibitory activity toward α-mannosidases
(Arkat USA, 2002)
Through the reductive amination of N-[(tert-butoxy)carbonyl]-2,5-dideoxy-2, 5-imino-3,4-O-isopropylidene-L-ribose with tetramethylenediamine, hexamethylenediamine, 2,7-diaminofluorene, 4,4′-diaminodiphenylmethane and ...
Artículo
Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
(Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2015)
The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported herein. Tetrava- lent and nonavalent dendrimers were obtained by means of the click chemistry approach ...
Artículo
Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry
(American Chemical Society, 2018)
The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in situ biological evaluation toward α -galactosidases has been carried out. The combination of the ...