Perfil del autor: Pastor Loro, Ángel Manuel
Datos institucionales
| Nombre | Pastor Loro, Ángel Manuel |
| Departamento | Fisiología |
| Área de conocimiento | Fisiología |
| Categoría profesional | Catedrático de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
59
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Nº visitas
6205
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Nº descargas
8298
| Publicaciones |
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Artículo
 VEGF expression disparities in brainstem motor neurons of the SOD1GP3A ALS model: Correlations with neuronal vulnerability
(Elsevier, 2024)
Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease characterized by severe muscle weakness mainly due to ... |
Artículo
Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells
(Frontiers Media, 2023)
The subventricular zone (SVZ) is a brain region that contains neural stem cells and progenitor cells (NSCs/NPCs) from which ... |
Artículo
Role of Vascular Endothelial Growth Factor as a Critical Neurotrophic Factor for the Survival and Physiology of Motoneurons
(Wolters Kluwer Health, 2023)
Vascular endothelial growth factor (VEGF) was discovered by its angiogenic activity. However, during evolution, it appeared ... |
Artículo
Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF
(Springer Nature, 2023)
The potassium chloride cotransporter 2 (KCC2) is the main Cl− extruder in neurons. Any alteration in KCC2 levels leads to ... |
Artículo
Relative contribution of lateral vestibular neuron and abducens internuclear neuron inputs to the discharge activity of medial rectus motoneurons
(Springer, 2023)
Medial rectus motoneurons mediate nasally directed horizontal eye movements. These motoneurons receive two major excitatory ... |
Artículo
Proprioceptors in extraocular muscles
(Wiley-Blackwell, 2023)
New Findings: What is the topic of this review? This review aims to evaluate the literature on proprioceptors and particular ... |
Artículo
BDNF Influence on Adult Terminal Axon Sprouting after Partial Deafferentation
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
BDNF is a neurotrophin family member implicated in many different neuronal functions, from neuronal survival during ... |
Artículo
VEGF and Neuronal Survival
(SAGE, 2022)
Vascular endothelial growth factor (VEGF) is well known for its angiogenic activity, but recent evidence has revealed a ... |
Artículo
Spinal cord from body donors is suitable for multicolor immunofluorescence
(Springer Nature, 2022)
Immunohistochemistry is a powerful tool for studying neuronal tissue from humans at the molecular level. Obtaining fresh ... |
Artículo
Eye Movements But Not Vision Drive the Development of Palisade Endings
(Association for Research in Vision and Ophthalmology, 2022)
PURPOSE. To test whether visual experience and/or eye movements drive the postnatal development of palisade endings in ... |
Artículo
 VEGF is an essential retrograde trophic factor for motoneurons
(National Academy of Sciences, 2022)
VEGF was initially discovered due to its angiogenic activity and therefore named "vascular endothelial growth factor."However, ... |
Tesis Doctoral
Estrategias reparativas en el sistema oculomotor tras la lesión mediante la administración del factor de crecimiento del endotelio vascular (VEGF)
(2021)
El factor de crecimiento del endotelio vascular (VEGF) es una proteína englobada en la familia de los factores tróficos. ... |
Artículo
MIF versus SIF motoneurons, what are their respective contribution in the oculomotor medial rectus pool?
(Society for Neuroscience, 2021)
Multiply-innervated muscle fibers (MIFs) are peculiar to the extraocular muscles as they are non-twitch but produce a slow ... |
Artículo
Neuroprotective Effect of Vascular Endothelial Growth Factor on Motoneurons of the Oculomotor System
(MDPI, 2021)
Vascular endothelial growth factor (VEGF) was initially characterized as a potent angiogenic factor based on its activity ... |
Artículo
Purinergic Receptor Blockade with Suramin Increases Survival of Postnatal Neural Progenitor Cells In Vitro
(MDPI, 2021)
Neural progenitor cells (NPCs) are self-renewing and multipotent cells that persist in the postnatal and adult brain in ... |
Artículo
Sources and lesion-induced changes of VEGF expression in brainstem motoneurons
(Springer Nature, 2020)
Motoneurons of the oculomotor system show lesser vulnerability to neurodegeneration compared to other cranial motoneurons, ... |
Artículo
Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles
(MDPI, 2020)
Extraocular muscles (EOMs) show resistance to muscle dystrophies and sarcopenia. It has been recently demonstrated that ... |
Artículo
A Single Intraventricular Injection of VEGF Leads to Long-Term Neurotrophic Effects in Axotomized Motoneurons
(Society for Neuroscience, 2020)
Vascular endothelial growth factor (VEGF) has been recently demonstrated to induce neuroprotective and synaptotrophic ... |
Artículo
Structural and molecular characteristics of axons in the long head of the biceps tendon
(Springer Nature, 2020)
The innervation of the long head of the biceps tendon (LHBT) is not sufficiently documented. This is a drawback since ... |
Artículo
Palisade endings have an exocytotic machinery but lack acetylcholine receptors and distinct acetylcholinesterase activity
(ARVO, 2020)
Purpose: The purpose of this work was to test whether palisade endings express structural and molecular features of ... |
Patente. Invención
Procedimiento para prolongar la vida media de células progenitoras neurales neonatales con suramina
(Oficina Española de Patentes y Marcas , 2019)
Uso de la suramina para prolongar la vida media de células progenitoras neurales neonatales.La presente invención se refiere ... |
Artículo
Functional diversity of motoneurons in the oculomotor system
(National Academy of Sciences, 2019)
Extraocular muscles contain two types of muscle fibers according to their innervation pattern: singly innervated muscle ... |
Artículo
Extracellular Vesicle-Mediated Communication between the Glioblastoma and Its Microenvironment
(MDPI, 2019)
The glioblastoma is the most malignant form of brain cancer. Glioblastoma cells use multiple ways of communication with ... |
Artículo
Short-term plasticity after partial deafferentation in the oculomotor system
(Springer Nature, 2019)
Medial rectus motoneurons are innervated by two main pontine inputs. The specific function of each of these two inputs ... |
Artículo
Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications
(Frontiers Media, 2019)
Human glioblastoma is the most aggressive type of primary malignant brain tumors. Standard treatment includes surgical ... |
Tesis Doctoral
Dependencias tróficas y sinápticas del sistema oculomotor.
(2018)
Las motoneuronas del recto medial presentes en el núcleo motor ocular común (NMOC) reciben dos entradas pontinas principales: ... |
Artículo
Vascular Endothelial Growth Factor (VEGF) Prevents the Downregulation of the Cholinergic Phenotype in Axotomized Motoneurons of the Adult Rat
(Frontiers Media, 2018)
Vascular endothelial growth factor (VEGF) was initially characterized by its activity on the vascular system. However, ... |
Artículo
Effects of Selective Deafferentation on the Discharge Characteristics of Medial Rectus Motoneurons
(Society for Neuroscience, 2018)
Medial rectus motoneurons receive two main pontine inputs: abducens internuclear neurons, whose axons course through the ... |
Artículo
Vascular endothelial growth factor: an essential neurotrophic factor for motoneurons?
(Medknow Publications, 2018)
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Artículo
Synaptic loss and firing alterations in Axotomized Motoneurons are restored by vascular endothelial growth factor (VEGF) and VEGF-B
(Elsevier, 2018)
Vascular endothelial growth factor (VEGF), also known as VEGF-A, was discovered due to its vasculogenic and angiogenic ... |
Artículo
Interactions between neural progenitor cells and microglia in the subventricular zone: physiological implications in the neurogenic niche and after implantation in the injured brain
(Frontiers Media, 2018)
The adult subventricular zone (SVZ) of the mammalian brain contains neural progenitor cells (NPCs) that continuously produce ... |
Artículo
Extraocular motoneurons of the adult rat show higher levels of vascular endothelial growth factor and its receptor Flk-1 than other cranial motoneurons
(Public Library of Science, 2017)
Recent studies show a relationship between the deficit of vascular endothelial growth factor (VEGF) and motoneuronal ... |
Artículo
Palisade endings of extraocular muscles develop postnatally following different time courses
(Association for Research in Vision and Ophthalmology, 2017)
PURPOSE. To analyze in a frontal-eyed mammal (cat) the postnatal development of palisade endings in extraocular muscles ... |
Artículo
Extraocular Motor System Exhibits a Higher Expression of Neurotrophins When Compared with Other Brainstem Motor Systems
(Frontiers Media, 2017)
Extraocular motoneurons resist degeneration in diseases such as amyotrophic lateral sclerosis. The main objective of the ... |
Artículo
Functional Diversity of Neurotrophin Actions on the Oculomotor System
(MDPI AG, 2016)
Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance ... |
Artículo
Palisade Endings Are a Constant Feature in the Extraocular Muscles of Frontal-Eyed, But Not Lateral-Eyed, Animals
(Association for Research in Vision and Ophthalmology, 2016)
Purpose To test whether palisade endings are a general feature of mammalian extraocular muscles (EOMs). Methods Thirteen ... |
Tesis Doctoral
Implante de progenitores neurales en un modelo de lesión del sistema oculomotor
(2015)
El implante de células progenitoras neurales en el sistema nervioso central lesionado es una poderosa herramienta reparadora. ... |
Tesis Doctoral
Reacción glial tras el implante de precursores neurales en un modelo de lesión del sistema nervioso central
(2015)
En el cerebro adulto existen dos regiones con capacidad neurogénica, el giro dentado del hipocampo y la zona subventricular ... |
Artículo
Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells
(Frontiers Research Foundation, 2015)
The postnatal subventricular zone (SVZ) lining the walls of the lateral ventricles contains neural progenitor cells (NPCs) ... |
Artículo
Neural Progenitor Cell Implants in the Lesioned Medial Longitudinal Fascicle of Adult Cats Regulate Synaptic Composition and Firing Properties of Abducens Internuclear Neurons
(Society for Neuroscience, 2014)
Transplants of neural progenitor cells (NPCs) into the injured CNS have been proposed as a powerful tool for brain repair, ... |
Artículo
Implanted neural progenitor cells regulate glial reaction to brain injury and establish gap junctions with host glial cells
(Wiley-Blackwell, 2014)
Transplantation of neural stem/progenitor cells (NPCs) in the lesioned brain is able to restore morphological and physiological ... |
| Artículo |
Artículo
Axons Giving Rise to the Palisade Endings of Feline Extraocular Muscles Display Motor Features
(Society for Neuroscience, 2013)
Palisade endings are nerve specializations found in the extraocular muscles (EOMs) of mammals, including primates. They ... |
Artículo
PSA-NCAM is expressed in immature, but not recently generated, neurons in the adult cat cerebral cortex layer II
(Frontiers Media S.A., 2011)
Neuronal production persists during adulthood in the dentate gyrus and the olfactory bulb, where substantial numbers of ... |
Artículo
Evidence that the extraocular motor nuclei innervate monkey palisade endings
(Elsevier, 2011)
Palisade endings are found in the extraocular muscles (EOMs) of almost every mammalian species, including primates. These ... |
Artículo
Dual encoding of muscle tension and eye position by abducens motoneurons
(Society for Neuroscience, 2011)
Extraocular muscle tension associated with spontaneous eye movements has a pulse-slide-step profile similar to that of ... |
Artículo
Differential regulation of the expression of neurotrophin receptors in rat extraocular motoneurons after lesion
(Wiley, 2011)
Neurotrophins acting through high-affinity tyrosine kinase receptors (trkA, trkB, and trkC) play a crucial role in regulating ... |
Artículo
The Use of PRV-Bartha to Define Premotor Inputs to Lumbar Motoneurons in the Neonatal Spinal Cord of the Mouse
(Public Library of Science, 2010)
Background The neonatal mouse has become a model system for studying the locomotor function of the lumbar spinal cord. ... |
Artículo
Nerve Growth Factor Regulates the Firing Patterns and Synaptic Composition of Motoneurons
(Society for Neuroscience, 2010)
Target-derived neurotrophins exert powerful synaptotrophic actions in the adult brain and are involved in the regulation ... |
Tesis Doctoral
Regulación neurotrófica de las propiedades de disparo y de la sinaptología aferente sobre las motoneuronas axotomizadas del núcleo motor ocular externo
(2010)
La teoría trófica de las conexiones neuronales establece que durante el desarrollo embrionario los órganos diana son ... |
Artículo
Complementary Actions of BDNF and Neurotrophin-3 on the Firing Patterns and Synaptic Composition of Motoneurons
(Society for Neuroscience, 2009)
Neurotrophins, as target-derived factors, are essential for neuronal survival during development, but during adulthood, ... |
Patente. Invención
Dispositivo para la administración de sustancias, estimulación y registro daser
(Oficina Española de Patentes y Marcas (OEPM), 2007)
Dispositivo para la administración de sustancias, estimulación y registro daser. Se trata de un dispositivo para uso ... |
Artículo
Regulation of Gephyrin Cluster Size and Inhibitory Synaptic Currents on Renshaw Cells by Motor Axon Excitatory Inputs
(Society for Neuroscience, 2005)
Renshaw cells receive a high density of inhibitory synapses characterized by large postsynaptic gephyrin clusters and mixed ... |
Patente. Invención
Electrodo de succión flotante.
(Oficina Española de Patentes y Marcas , 2004)
Electrodo de succión flotante.Se trata de un dispositivo de registro neurofisiológico que permite la monitorización eléctrica ... |
Tesis Doctoral
Efectos de la reinervación de una nueva diana por neuronas centrales axotomizadas
(2004)
Se realizó un estudio de los efectos de un implante de primordio cerebeloso como posible nueva diana para las neuronas ... |
| Artículo |
Patente. Invención
Discriminador de formas de potenciales de acción
(Oficina Española de Patentes y Marcas (OEPM), 1998)
Discriminador de formas de potenciales de acción, que permite seleccionar, dentro de un tren de potenciales de acción o ... |
Patente. Invención
Sistema de adquisición de datos ininterrumpido en tiempo real
(Oficina Española de Patentes y Marcas (OEPM), 1997)
Sistema de adquisición de datos ininterrumpido en tiempo real, que permite la monitorización y el almacenamiento en memoria ... |
Artículo
Eye position and eye velocity integrators reside in separate brainstem nuclei.
(National Academy of Sciences, 1994)
Two types of central nervous system integrators are critical for oculomotor performance. The first integrates velocity ... |