Artículo
Association between sleep-disordered breathing and breast cancer aggressiveness
Autor/es | Campos Rodríguez, Francisco José
Cruz-Medina, Antonio Selma, María José Rodríguez-de-la-Borbolla-Artacho, María Sanchez-Vega, Adrian Ripoll-Orts, Francisco Almeida González, Carmen V. Martinez-Garcia, Miguel Angel |
Departamento | Instituto de Biomedicina de Sevilla (IBIS) |
Fecha de publicación | 2018-11-21 |
Fecha de depósito | 2019-01-16 |
Publicado en |
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Resumen | Background
Sleep-disordered breathing (SDB) has been associated with cancer aggressiveness, but studies focused on specific tumors are lacking. In this pilot study we investigated whether SDB is associated with breast ... Background Sleep-disordered breathing (SDB) has been associated with cancer aggressiveness, but studies focused on specific tumors are lacking. In this pilot study we investigated whether SDB is associated with breast cancer (BC) aggressiveness. Methods 83 consecutive women <65 years diagnosed with primary BC underwent a home respiratory polygraphy. Markers of SDB severity included the apnea-hypopnea index (AHI) and the 4% oxygen desaturation index (ODI4). The Ki67 proliferation index, lack of hormone receptors (HR-), Nottingham Histological Grade (NHG), and tumor stage were used as markers of BC aggressiveness. The association between SDB and molecular subtypes of BC was also assessed. Results The mean (SD) age was 48.8 (8.8) years and body mass index was 27.4 (5.4) Kg/m2. 42 women (50.6%) were post-menopausal. The median (IQR) AHI was 5.1 (2–9.4), and ODI4 was 1.5 (0.5–5.8). The median (IQR) AHI did not differ between the groups with Ki67>28% and Ki67<29% [5.1 (2.6–8.3) vs 5.0 (1.5–10), p = 0.89)], HR- and HR+ [5.7 (1.6–12.4) vs 4.9 (2–9.4), p = 0.68], NHG (Grade3, Grade2, and Grade1; p = 0.86), tumor stage (stage III-IV, stage II, and stage I; p = 0.62), or molecular subtypes (Luminal A, Luminal B, HER2, and triple negative; p = 0.90). The prevalence of an AHI≥5 did not differ between the groups with Ki67>28% and Ki67<29% (51.2% vs 52.3%, p = 0.90), HR- and HR+ (58.3% vs 49.1%, p = 0.47), NHG categories (p = 0.89), different tumor stages (p = 0.71), or molecular subtypes (p = 0.73). These results did not change when the ODI4 was used instead of the AHI. Conclusion Our results do not support an association between the presence or severity of SDB and BC aggressiveness. |
Agencias financiadoras | Asociación de Neumología y Cirugía Torácica del Sur (NEUMOSUR) |
Identificador del proyecto | 1/2015 |
Cita | Campos-Rodríguez, F., Cruz-Medina, A., Selma, M.J., Rodríguez-de-la-Borbolla-Artacho, M., Sanchez-Vega, A., Ripoll-Orts, F.,...,Martinez-Garcia, M.A. (2018). Association between sleep-disordered breathing and breast cancer aggressiveness. PloS one, 13 (11), e0207591-1-e0207591-14. |
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