Artículo
miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation
Autor/es | López Beas, Javier
Capilla González, Vivian Aguilera, Yolanda Mellado, Nuria Lachaud, Christian Martín, Franz Smani Hajami, Tarik Soria Escoms, Bernat Hmadcha, Abdelkrim |
Departamento | Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) Instituto de Biomedicina de Sevilla (IBIS) |
Fecha de publicación | 2018-09-07 |
Fecha de depósito | 2018-08-20 |
Publicado en |
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Resumen | Human pluripotent stem cells retain the extraordinary capacity to differentiate into pancreatic beta cells. For this particular lineage, more effort is still required to stress the importance of developing an efficient, ... Human pluripotent stem cells retain the extraordinary capacity to differentiate into pancreatic beta cells. For this particular lineage, more effort is still required to stress the importance of developing an efficient, reproducible, easy, and cost-effective differentiation protocol to obtain more mature, homogeneous, and functional insulin-secreting cells. In addition, microRNAs (miRNAs) have emerged as a class of small non-coding RNAs that regulate many cellular processes, including pancreatic differentiation. Some miRNAs are known to be preferentially expressed in islets. Of note, miR-375 and miR-7 are two of the most abundant pancreatic miRNAs, and they are necessary for proper pancreatic islet development. Here we provide new insight into specific miRNAs involved in pancreatic differentiation. We found that miR-7 is differentially expressed during the differentiation of human embryonic stem cells (hESCs) into a beta cell-like phenotype and that its modulation plays an important role in generating mature pancreatic beta cells. This strategy may be exploited to optimize the potential for in vitro differentiation of hESCs into insulin-producing beta-like cells for use in preclinical studies and future clinical applications as well as the prospective uses of miRNAs to improve this process. |
Identificador del proyecto | BFU2016-74932-C2
BFU2013-45564-C2 PI-0272-2017 BM1305 CD16/00118 PI16/00259 PI17/02104 RD16/0011/0034 CD16/00118 |
Cita | López Beas, J., Capilla-González, V., Aguilera, Y., Mellado, N., Lachaud, C., Martín, F.,...,Hmadcha, A. (2018). miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation. Molecular Therapy Nucleic Acids, 12, 463-477. |
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