Article
Highly enantioselective hydrogenation of 1-alkylvinyl benzoates: A simple, nonenzymatic access to chiral 2-alkanols
Author/s | Kleman, Patryk Artur
González Liste, Pedro J. García Garrido, Sergio E. Cadierno, Victorio Pizzano Mancera, Antonio |
Publication Date | 2013 |
Deposit Date | 2018-02-20 |
Published in |
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Abstract | Going chiral! Highly enantioselective catalytic hydrogenations of enol esters 1 by using a Rh catalyst bearing a POP ligand are described (see scheme; NBD=norbornadiene). The catalytic system has a broad scope and allows ... Going chiral! Highly enantioselective catalytic hydrogenations of enol esters 1 by using a Rh catalyst bearing a POP ligand are described (see scheme; NBD=norbornadiene). The catalytic system has a broad scope and allows the preparation of a wide range of chiral esters 2 bearing diverse alkyls or a benzyl group with high enantioselectivities. These esters can easily be converted in highly enantioenriched 2-alkanols. |
Funding agencies | Ministerio de Ciencia e Innovación (MICIN). España Junta de Andalucía |
Project ID. | CTQ2009-11867
CTQ2010-14796 CSD2007-00006 2008/ FQM-3830 2009/FQM-4832 |
Citation | Kleman, P.A., González Liste, P.J., García Garrido, S.E., Cadierno, V. y Pizzano Mancera, A. (2013). Highly enantioselective hydrogenation of 1-alkylvinyl benzoates: A simple, nonenzymatic access to chiral 2-alkanols. Chemistry - A European Journal, 19, 16209-16212. |
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