Article
Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (McM-41) for enhancing drug delivery capability
Author/s | Boccardi, Elena
Philippart, Anahí Juhasz-Bortuzzo, Judith A. Beltrán, Ana M. Novajra, Giorgia Vitale-Brovarone, Chiara Spiecker, Erdmann Boccaccini, Aldo R. |
Department | Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte |
Publication Date | 2015 |
Deposit Date | 2018-01-05 |
Published in |
|
Abstract | The design and characterization of a new family of multifunctional scaffolds based on bioactive glass (BG) of 45S5 composition for bone tissue engineering and drug delivery applications are presented. These BG-based scaffolds ... The design and characterization of a new family of multifunctional scaffolds based on bioactive glass (BG) of 45S5 composition for bone tissue engineering and drug delivery applications are presented. These BG-based scaffolds are developed via a replication method of polyurethane packaging foam. In order to increase the therapeutic functionality, the scaffolds were coated with mesoporous silica particles (MCM-41), which act as an in situ drug delivery system. These sub-micron spheres are characterized by large surface area and pore volume with a narrow pore diameter distribution. The solution used for the synthesis of the silica mesoporous particles was designed to obtain a high-ordered mesoporous structure and spherical shape – both are key factors for achieving the desired controlled drug release. The MCM-41 particles were synthesized directly inside the BG-based scaffolds, and the drug-release capability of this combined system was evaluated. Moreover, the effect of MCM-41 particle coating on the bioactivity of the BG-based scaffolds was assessed. The results indicate that it is possible to obtain a multifunctional scaffold system characterized by high and interconnected porosity, high bioactivity, and sustained drug delivery capability. |
Funding agencies | European Union (UE). FP7 |
Project ID. | EU ITN FP-7 |
Citation | Boccardi, E., Philippart, A., Juhasz-Bortuzzo, J.A., Beltrán, A.M., Novajra, G., Vitale-Brovarone, C.,...,Boccaccini, A.R. (2015). Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (McM-41) for enhancing drug delivery capability. Frontiers in Bioengineering and Biotechnology, 3 |
Files | Size | Format | View | Description |
---|---|---|---|---|
Beltran_FBandB_2015_uniform.pdf | 11.79Mb | [PDF] | View/ | |