Artículo
Uptake and intracellular activity of an optically active ofloxacin isomer in human neutrophils and tissue culture cells
Autor/es | Pascual Hernández, Álvaro
García Luque, Isabel Perea Pérez, Evelio José |
Departamento | Universidad de Sevilla. Departamento de Microbiología |
Fecha de publicación | 1990-01-01 |
Fecha de depósito | 2017-09-28 |
Publicado en |
|
Resumen | The penetration of an optically active ofloxacin isomer [(-)-ofloxacin] into human neutrophils and different tissue culture cells (HEp-2, McCoy, MDCK, and Vero) was studied and compared with that of ofloxacin by a fluorometric ... The penetration of an optically active ofloxacin isomer [(-)-ofloxacin] into human neutrophils and different tissue culture cells (HEp-2, McCoy, MDCK, and Vero) was studied and compared with that of ofloxacin by a fluorometric assay. The cellular-to-extracellular-concentration ratios (C/E) of (-)-ofloxacin were always higher than 6, significantly greater than those of ofloxacin at extracellular concentrations of 5 and 10 mg/liter. The penetration of (-)-ofloxacin and ofloxacin was doubled when neutrophils were stimulated by phorbol myristate acetate but not affected after ingestion of opsonized Staphylococcus aureus. The C/E ratios of (-)-ofloxacin and ofloxacin for different tissue culture epithelial cells and fibroblasts were lower than those of neutrophils but still higher than 2. Both compounds produced a significant reduction in viable intraphagocytic S. aureus during 3 h of exposure to antimicrobial agents. We conclude that (-)-ofloxacin appears to reach higher intracellular concentrations than ofloxacin, remaining active inside the neutrophils. |
Cita | Pascual Hernández, Á., García Luque, I. y Perea Pérez, E.J. (1990). Uptake and intracellular activity of an optically active ofloxacin isomer in human neutrophils and tissue culture cells. Antimicrobial Agents and Chemotherapy, 34 (2), 277-280. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Uptake and intracellular activity ... | 664.5Kb | [PDF] | Ver/ | |