Article
Activities of imipenem and cephalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal β-lactamase and showing altered porin profiles
Author/s | Martínez Martínez, Luis
Conejo Gonzalo, Mª Carmen Pascual Hernández, Álvaro Hernández Allés, Santiago Ramírez de Arellano Ramos, E. Benedí, Vicente J. Perea Pérez, Evelio José |
Department | Universidad de Sevilla. Departamento de Microbiología |
Publication Date | 2000-09-06 |
Deposit Date | 2017-08-17 |
Published in |
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Abstract | Forty clonally related clinical isolates of Escherichia coli from hospitalized patients were resistant to cefoxitin (MICs, >256 μg/ml) and ceftazidime (MICs, 32 to 256 μg/ml) and were intermediate or resistant to cefotaxime ... Forty clonally related clinical isolates of Escherichia coli from hospitalized patients were resistant to cefoxitin (MICs, >256 μg/ml) and ceftazidime (MICs, 32 to 256 μg/ml) and were intermediate or resistant to cefotaxime (MICs, 16 to 128 μg/ml) but susceptible to both cefepime (MICs, 0.5 to 2 μg/ml) and imipenem (MICs, 0.125 to 0.25 μg/ml). Resistance to β-lactams was related to high-level production of AmpC β-lactamase and loss of OmpF porin. |
Citation | Martínez Martínez, L., Conejo Gonzalo, M.C., Pascual Hernández, Á., Hernández Allés, S., Ramírez de Arellano Ramos, E., Benedí, V.J. y Perea Pérez, E.J. (2000). Activities of imipenem and cephalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal β-lactamase and showing altered porin profiles. Antimicrobial Agents and Chemotherapy, 44 (9), 2534-2536. |
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