Artículo
Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth
Autor/es | Iglesias Linares, Alejandro
Yañez-Vico, Rosa Ballesta Mudarra, Sofía Ortiz-Ariza, Estefanía Mendoza Mendoza, María Asunción Perea Pérez, Evelio José Moreno-Fernández, Ana María Solano Reina, José Enrique |
Departamento | Universidad de Sevilla. Departamento de Estomatología Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica |
Fecha de publicación | 2013-04-30 |
Fecha de depósito | 2017-06-05 |
Publicado en |
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Resumen | External pical root resorption (EARR) is a frequent iatrogenic problem following orthodontic treatment in endodontically-treated teeth, about which the literature reports substantial variability in post-orthodontic treatment ... External pical root resorption (EARR) is a frequent iatrogenic problem following orthodontic treatment in endodontically-treated teeth, about which the literature reports substantial variability in post-orthodontic treatment EARR responses. The main focus of the present study is to clarify whether variants in the interleukin-1 receptor antagonist gene coding for the IL-1ra protein have a positive/negative influence on EARR of endodontically-treated teeth. Ninety-three orthodontic patients were genetically screened for a single nucleotide polymorphism (SNP: rs419598) in the IL1 cluster. The sample was classified into 2 groups: group 1 (affected-group) showed radiographic EARR of more than 2mm; group 2 (control-group), had no EARR or EARR <= to 2mm following orthodontic treatment on root-filled teeth. Logistic regression analysis was performed to obtain an adjusted estimate between the SNPs studied and EARR. Genotype distributions, allelic frequencies, adjusted odds ratios (OR) and 95% confidence intervals were also calculated. We found that subjects homozygous [1/1(TT)] for the IL1RN gene [OR: 10.85; p=0.001; CI: 95%] were at risk of EARR in root-filled teeth. Genetic variants in the antagonist axis balance of the IL1RN(rs419598) have a direct repercussion on the predisposition to post-orthodontic EARR in root-filled teeth. Variants in allele 1 of the interleukin-1 receptor antagonist gene(rs419598) are associated(p=0.001**) with an increased risk of suffering post-orthodontic EARR in root-filled teeth. |
Cita | Iglesias Linares, A., Yañez-Vico, R., Ballesta Mudarra, S., Ortiz-Ariza, E., Mendoza Mendoza, M.A., Perea Pérez, E.J.,...,Solano Reina, J.E. (2013). Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth. Histology and Histopathology, 28 (6), 767-773. |
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