Artículo
The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles
Autor/es | Muñiz Guinea, Manuel
Nuoffer, Claude Hauri, Hans Peter Riezman, Howard |
Departamento | Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2000 |
Fecha de depósito | 2016-04-19 |
Publicado en |
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Resumen | Members of the yeast p24 family, including
Emp24p and Erv25p, form a heteromeric complex re-
quired for the efficient transport of selected proteins
from the endoplasmic reticulum (ER) to the Golgi ap-
paratus. The ... Members of the yeast p24 family, including Emp24p and Erv25p, form a heteromeric complex re- quired for the efficient transport of selected proteins from the endoplasmic reticulum (ER) to the Golgi ap- paratus. The specific functions and sites of action of this complex are unknown. We show that Emp24p is di- rectly required for efficient packaging of a lumenal cargo protein, Gas1p, into ER-derived vesicles. Emp24p and Erv25p can be directly cross-linked to Gas1p in ER-derived vesicles. Gap1p, which was not af- fected by emp24 mutation, was not cross-linked. These results suggest that the Emp24 complex acts as a cargo receptor in vesicle biogenesis from the ER |
Ficheros | Tamaño | Formato | Ver | Descripción |
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The emp24 complex.pdf | 203.0Kb | [PDF] | Ver/ | |