Química Orgánica
Colecciones en esta comunidad
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Artículo
Self-association of a naphthalene-capped-β-cyclodextrin through cooperative strong hydrophobic interactions
(Elsevier, 2011-09-05)NMR, circular dichroism and fluorescence techniques were used to study the structure in solution of a new β-cyclodextrin ...
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Artículo
Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery
(Elsevier, 2011-10)Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a ...
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Artículo
A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition
(Wiley-Blackwell, 2022-10-10)Fully substituted peptide/[60]fullerene hexakis-adducts offer an excellent opportunity for multivalent protein recognition. ...
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Artículo
Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity
(Royal Society of Chemistry, 2024-03-05)A novel family of precision-engineered gene vectors with well-defined structures built on trehalose and trehalose-based ...
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Artículo
Deep Eutectic Solvents as Catalysts in the Synthesis of Active Pharmaceutical Ingredients and Precursors
(MDPI, 2024-02-02)Deep Eutectic Solvents (DESs) have appeared in recent years as an appealing alternative to classical organic solvents, due ...
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Artículo
Organocatalysis and Biocatalysis Hand in Hand: Combining Catalysts in One-Pot Procedures
(Wiley, 2017)Multi-step processes catalysed by several catalysts working concurrently have been developed in nature, thus improving ...
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Artículo
Tacrine-sugar mimetic conjugates as enhanced cholinesterase inhibitors
(Royal Society of Chemistry, 2021-03-14)We have used the Cu(i)-catalyzed azide-alkyne Huisgen cycloaddition reaction to obtain two families of bivalent heterodimers ...
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Artículo
Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations
(Elsevier, 2019-10-01)Herein we report a straightforward preparation of new antiproliferative agents based on the hybridization of a coumarin ...
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Artículo
Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs
(Elsevier, 2018-01-01)Herein we report the straightforward preparation of novel conformationally-restricted steroids from trans-androsterone and ...
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Artículo
Biotinylated selenocyanates: Potent and selective cytostatic agents
(Elsevier, 2023-04)Most of the currently available cytotoxic agents for tackling cancer are devoid of selectivity, thus causing severe ...
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Artículo
Cyclopentyl Methyl Ether (CPME): A Versatile Eco-Friendly Solvent for Applications in Biotechnology and Biorefineries
(Wiley, 2019-05)The quest for sustainable solvents is currently a matter of intense research and development, as solvents significantly ...
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Artículo
Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using Pd0-CalB CLEA as a Biohybrid Catalyst
(Wiley, 2019-07-11)Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross-linked enzyme ...
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Artículo
Biocatalytic Atroposelective Synthesis of Axially Chiral N-Arylindoles via Dynamic Kinetic Resolution
(American Chemical Society, 2022-12-22)A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of configurationally labile N-arylindole aldehydes ...
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Artículo
N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study
(Elsevier, 2020-05)Our goal was the evaluation of a series of N-1,2,3-triazole-isatin derivatives for multi-target activity which included ...
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Artículo
Chemoenzymatic synthesis and radical scavenging of sulfated hydroxytyrosol, tyrosol, and acetylated derivatives
(American Chemical Society, 2019-07-03)Potential metabolites of bioactive compounds are important for their biological activities and as authentic standards for ...
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Artículo
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors
(Elsevier, 2019-11-01)Concerned by the devastating effects of Alzheimer's disease, and the lack of effective drugs, we have carried out the ...
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Artículo
Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease
(Elsevier, 2022-10)Concerned by the urgent need to explore new approaches for the treatment of Alzheimer's disease, we herein describe the ...
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Artículo
Preparation of water-soluble glycopolymers derived from five-membered iminosugars
(Elsevier, 2019-10)Iminosugars are carbohydrate mimetics that constitute the main group of oligosaccharide processing enzyme inhibitors. ...
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Artículo
A Complex Regulatory Network Governs the Expression of Symbiotic Genes in Sinorhizobium Fredii HH103
(Frontiers Media, 2023)Introduction: The establishment of the rhizobium-legume nitrogen-fixing symbiosis relies on the interchange of molecular ...
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Patente. Invención
Nuevos caramelos con elevado contenido en oligosacáridos prebióticos, procedimiento de preparación y utilización
(Organización Mundial de la Propiedad Intelectual (OMPI), 2009-12-30)La presente invención se refiere a la transformación de azúcares alimentarios que contienen D-fructosa, en caramelos ...