dc.creator | Pavillard, Luis E. | es |
dc.creator | Cañadas Lozano, Diego | es |
dc.creator | Alcocer-Gómez, Elísabet | es |
dc.creator | Marin Aguilar, Fabiola | es |
dc.creator | Pereira Arenas, Sheila | es |
dc.creator | Robertson, Avril | es |
dc.creator | Muntané Relat, Jordi | es |
dc.creator | Bullon, Pedro | es |
dc.creator | Cordero, Mario D. | es |
dc.date.accessioned | 2020-05-13T10:52:50Z | |
dc.date.available | 2020-05-13T10:52:50Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Pavillard, L.E., Cañadas Lozano, D., Alcocer-Gómez, E., Marin Aguilar, F., Pereira Arenas, S., Robertson, A.,...,Cordero, M.D. (2017). NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction. Oncotarget, 8 (59), 99740-99756. | |
dc.identifier.issn | 1949-2553 | es |
dc.identifier.uri | https://hdl.handle.net/11441/96548 | |
dc.description.abstract | The NLRP3-inflammasome complex has emerged as an important component of
inflammatory processes in metabolic dysfunction induced by high-caloric diets. In
this study, we investigate the molecular mechanisms by which NLRP3 inhibition may
attenuate diet-induced cardiac injury. Here we show the cardiac damage induced
by high sugar diet (HSD), high fat diet (HFD) or high sugar/fat diet (HSFD) over
15 weeks. Genetic ablation of NLRP3 protected against this damage by autophagy
induction and apoptotic control. Furthermore, NLRP3 inhibition by the selective small
molecule MCC950 resulted in similar autophagy induction and apoptotic control in
hearts after diets. These data were reproduced in THP-1 cells treated with MCC950 and
cultured in media supplemented with serum from mice dosed with MCC950 and fed
with diets. NLRP3 inhibition exerted beneficial metabolic, and autophagic adaptations
in hearts from obesogenic diets. The inhibition of NLRP3 activation may hold promise
in the treatment of metabolic and cardiovascular diseases. | es |
dc.description.sponsorship | Junta de Andalucía CTS113 | es |
dc.description.sponsorship | Junta de Andalucia PI-0036-2014 | es |
dc.format | application/pdf | es |
dc.format.extent | 17 | es |
dc.language.iso | eng | es |
dc.publisher | Impact Journals | es |
dc.relation.ispartof | Oncotarget, 8 (59), 99740-99756. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cardiac damage | es |
dc.subject | Autophagy | es |
dc.subject | NLRP3-inflammasome | es |
dc.subject | MCC950 | es |
dc.title | NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Instituto de Biomedicina de Sevilla (IBIS) | es |
dc.identifier.doi | 10.18632/oncotarger 20763 | es |
dc.journaltitle | Oncotarget | es |
dc.publication.volumen | 8 | es |
dc.publication.issue | 59 | es |
dc.publication.initialPage | 99740 | es |
dc.publication.endPage | 99756 | es |