Article
Dietary fatty acids and lipoproteins on progression of age-related macular degeneration
Author/s | Montserrat de la Paz, Sergio
Naranjo Gutiérrez, María del Carmen Bermúdez Pulgarín, Beatriz López Martín, Sergio Abia González, María del Rocío García Muriana, Francisco José |
Department | Universidad de Sevilla. Departamento de Bioquímica médica y Biología molecular e Inmunología Universidad de Sevilla. Departamento de Biología celular |
Publication Date | 2017 |
Deposit Date | 2020-04-21 |
Published in |
|
Abstract | Age-related macular degeneration (AMD) is a medical condition of central loss vision and blindness. Numerous studies have revealed that changes on certain dietary fatty acids (FAs) could have useful for AMD management. ... Age-related macular degeneration (AMD) is a medical condition of central loss vision and blindness. Numerous studies have revealed that changes on certain dietary fatty acids (FAs) could have useful for AMD management. This review summarizes the effects of dietary omega-3 long-chain PUFAs, MUFAs, and SFAs, and lipoproteins on AMD. Findings are consistent with the beneficial role of dietary omega-3 long-chain PUFAs, while the effects of dietary MUFAs and SFAs appeared to be ambiguous with respect to the possible protection from MUFAs and to the possible adverse impact from SFAs on AMD. Some of the pathological mechanisms associated with lipoproteins on AMD share those observed previously in cardiovascular diseases. It was also noticed that the effects of FAs in the diet and lipoprotein on AMD could be modulated by genetic variants. From a population health perspective, the findings of this review are in favour of omega-3 long-chain FAs recommendations in a preventive and therapeutic regimen to attain lower AMD occurrence and progression rates. Additional long-term and short-term nutrigenomic studies are required to clearly establish the role and the relevance of interaction of dietary FAs, lipoproteins, and genes in the genesis and progression of AMD. |
Citation | Montserrat de la Paz, S., Naranjo Gutiérrez, M.d.C., Bermúdez Pulgarín, B., López Martín, S., Abia González, M.d.R. y García Muriana, F.J. (2017). Dietary fatty acids and lipoproteins on progression of age-related macular degeneration. Grasas y aceites. International Journal of Fats and Oils, 68 (2), 1-7. |
Files | Size | Format | View | Description |
---|---|---|---|---|
Dietary fatty acids and lipopr ... | 872.0Kb | [PDF] | View/ | |