Artículo
Dual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic molecules
Autor/es | Massaro, M.
Riela, S. Baiamonte, C. Jiménez Blanco, José Luis Giordano, C. Lo Meo, P Milioto, S. Noto, R. |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2016 |
Fecha de depósito | 2020-04-15 |
Publicado en |
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Resumen | A dual drug-loaded HNT–CD glycocluster delivery system based on halloysite nanotubes and carbohydrate functionalized cyclodextrin was developed by a green protocol using solvent-free microwave irradiation. The nanohybrid ... A dual drug-loaded HNT–CD glycocluster delivery system based on halloysite nanotubes and carbohydrate functionalized cyclodextrin was developed by a green protocol using solvent-free microwave irradiation. The nanohybrid was employed for concurrent load and release of silibinin and curcumin. The new delivery system was characterized by means of TGA, FT-IR spectroscopy, SEM and DLS. These techniques confirm the successful loading of the two drugs in the system. SEM and DLS measurements highlighted that the nanomaterial preserves a tubular structure with an average hydrodynamic radius of ca. 200 nm. The release of the drugs from the HNT glycocluster was investigated by means of UV-vis spectroscopy at two different pH values simulanting the typical physiological conditions of either gastric or intestinal fluids. Enzyme-linked lectin assays (ELLA) demonstrated that highly mannoside–cyclodextrins HNT entities display high affinity towards mannose selective ConA lectin. Biological assays showed that the new drug delivery system exhibits anti-proliferative activity against the investigated cell lines. Fluorescence microscopy confirmed ELLA results and it showed a high propensity of this drug delivery system to cross cell membranes and to penetrate into the cell nucleus. The results revealed that the synthesized multicavity system is a material of suitable size and nanoarchitecture to transport drugs into living cells. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España |
Identificador del proyecto | SAF2013-44021-R |
Cita | Massaro, M., Riela, S., Baiamonte, C., Jiménez Blanco, J.L., Giordano, C., Lo Meo, P.,...,Noto, R. (2016). Dual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic molecules. RSC Advances, 91, 87935-87944. |
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