dc.creator | Marín-Aguilar, Fabiola | es |
dc.creator | Lechuga‐Vieco, A.V. | |
dc.creator | Alcocer-Gómez, Elízabet | |
dc.creator | Castejón Vega, Beatriz | |
dc.creator | Lucas, Javier | |
dc.creator | Garrido, Carlos | |
dc.creator | Peralta García, Alejandro | |
dc.creator | Pérez‐Pulido, Antonio J. | |
dc.creator | Varela‐López, Alfonso | |
dc.creator | Bullon, Pedro | |
dc.creator | Cordero, Mario D. | |
dc.date.accessioned | 2020-03-31T09:17:02Z | |
dc.date.available | 2020-03-31T09:17:02Z | |
dc.date.issued | 2019-09-23 | |
dc.identifier.citation | Marín-Aguilar, F., Alcocer-Gómez, E., Castejón Vega, B. y Bullon, P. (2019). NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.. Aging Cell, 19 (1), 1-14. | |
dc.identifier.issn | 1474-9726 | es |
dc.identifier.uri | https://hdl.handle.net/11441/94723 | |
dc.description.abstract | While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role
in physiological cardiac aging is largely unknown. During aging, many alterations
occur in the organism, which are associated with progressive impairment of metabolic
pathways related to insulin resistance, autophagy dysfunction, and inflammation.
Here, we investigated the molecular mechanisms through which NLRP3 inhibition
may attenuate cardiac aging. Ablation of NLRP3‐inflammasome protected mice from
age‐related increased insulin sensitivity, reduced IGF‐1 and leptin/adiponectin ratio
levels, and reduced cardiac damage with protection of the prolongation of the age‐
dependent PR interval, which is associated with atrial fibrillation by cardiovascular
aging and reduced telomere shortening. Furthermore, old NLRP3 KO mice showed an
inhibition of the PI3K/AKT/mTOR pathway and autophagy improvement, compared
with old wild mice and preserved Nampt‐mediated NAD + levels with increased SIRT1
protein expression. These findings suggest that suppression of NLRP3 prevented
many age‐associated changes in the heart, preserved cardiac function of aged mice
and increased lifespan. | es |
dc.description.sponsorship | Junta de Andalucía, Consejería de Salud [PI-0036-2014] | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad [SAF2017-84494-C2-1-R] | es |
dc.format | application/pdf | es |
dc.format.extent | 14 | es |
dc.language.iso | eng | es |
dc.publisher | John Wiley & Sons Ltd and The Anatomical Society | es |
dc.relation.ispartof | Aging Cell, 19 (1), 1-14. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Autophagy | es |
dc.subject | Cardiac aging | es |
dc.subject | Longevity | es |
dc.subject | Morbidity | es |
dc.subject | NLRP3‐inflammasome | es |
dc.title | NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice. | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estomatología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psicología Experimental | es |
dc.relation.publisherversion | https://doi.org/10.1111/acel.13050 | es |
dc.identifier.doi | 10.1111/acel.13050 | es |
dc.journaltitle | Aging Cell | es |
dc.publication.volumen | 19 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 14 | es |