Artículo
R Loops: From Physiologicalto Pathological Roles
Autor/es | García Muse, Tatiana
Aguilera López, Andrés |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2019-10-17 |
Fecha de depósito | 2020-02-18 |
Publicado en |
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Resumen | DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional structures with a negative impact on transcription, replication and DNA repair. Accumulating ... DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional structures with a negative impact on transcription, replication and DNA repair. Accumulating evidence suggests that they constitute a source of replication stress, DNA breaks and genome instability. Reciprocally, DNA breaks facilitate DNA-RNA hybrid formation by releasing the double helix torsional conformation. Cells avoid DNA-RNA accumulation by either preventing or removing hybrids directly or by DNA repair-coupled mechanisms. Given the R-loop impact on chromatin and genome organization and its potential relation with genetic diseases, we review R-loop homeostasis as well as their physiological and pathological roles. |
Identificador del proyecto | ERC2014 AdG669898 TARLOOP
BFU2016-75058-P BIO1238 |
Cita | García Muse, T. y Aguilera López, A. (2019). R Loops: From Physiologicalto Pathological Roles. Cell, 179 (3), 604-618. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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10.1016_j.cell.2019.08.055.pdf | 460.2Kb | [PDF] | Ver/ | Postprint |