Artículo
Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF
Autor/es | García Pastor, Lucía
Sánchez Romero, María Antonia Jakomin, Marcello Puerta Fernández, Elena Casadesús Pursals, Josep |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2019-09-05 |
Fecha de depósito | 2020-01-24 |
Publicado en |
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Premios | Premio Anual Publicación Científica Destacada de la US. Facultad de Biología Premio Anual Publicación Científica Destacada de la US. Facultad de Biología |
Resumen | Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon ... Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon itself. StdE activates transcription of the hdfR gene, and StdF activates std transcription together with HdfR. Binding of HdfR upstream of the std promoter is hindered by methylation of GATC sites located within the upstream activating sequence (UAS). Epigenetic control by Dam methylation thus antagonizes formation of the StdE-StdF-HdfR loop and tilts the std switch toward the StdOFF state. In turn, HdfR binding hinders methylation of the UAS, permitting activation of the StdE-StdF-HdfR loop and concomitant formation of StdON cells. Bistability is thus the outcome of competition between DNA adenine methylation and the StdE-StdF-HdfR activator loop. |
Identificador del proyecto | BIO2016–75235-P |
Cita | García Pastor, L., Sánchez Romero, M.A., Jakomin, M., Puerta Fernández, E. y Casadesús Pursals, J. (2019). Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF. Nucleic Acids Research, 47 (15), 7929-7941. |
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