Artículo
Transcription-mediated replication hindrance: a major driver of genome instability
Autor/es | Gómez González, Belén
Aguilera López, Andrés |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2019 |
Fecha de depósito | 2019-11-25 |
Publicado en |
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Resumen | Genome replication involves dealing with obstacles that
can result from DNA damage but also from chromatin alterations, topological stress, tightly bound proteins or
non-B DNA structures such as R loops. Experimental ... Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA structures such as R loops. Experimental evidence reveals that an engaged transcription machinery at the DNA can either enhance such obstacles or be an obstacle itself. Thus, transcription can become a potentially hazardous process promoting localized replication fork hindrance and stress, which would ultimately cause genome instability, a hallmark of cancer cells. Understanding the causes behind transcription–replication conflicts as well as how the cell resolves them to sustain genome integrity is the aim of this review. |
Cita | Gómez González, B. y Aguilera López, A. (2019). Transcription-mediated replication hindrance: a major driver of genome instability. Genes and Development, 33 (15-16), 1008-1026. |
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pub1008.pdf | 1.324Mb | [PDF] | Ver/ | |