Artículo
Neuroprotective Effects of Diets Containing Olive Oil and DHA/EPA in a Mouse Model of Cerebral Ischemia
Autor/es | Gonzalo Gobernado, Rafael
Ayuso, María Irene Sansone, Loredana Bernal Jiménez, Juan José Ramos Herrero, Víctor Darío Sánchez García, Enrique Ramos, Teresa L. Abia González, María del Rocío García Muriana, Francisco José Bermúdez Pulgarín, Beatriz Montaner, Joan |
Departamento | Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2019 |
Fecha de depósito | 2019-07-05 |
Publicado en |
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Resumen | Stroke is one of the leading causes of death worldwide and while there is increasing evidence that a Mediterranean diet might decrease the risk of a stroke, the effects of dietary fat composition on stroke outcomes have ... Stroke is one of the leading causes of death worldwide and while there is increasing evidence that a Mediterranean diet might decrease the risk of a stroke, the effects of dietary fat composition on stroke outcomes have not been fully explored. We hypothesize that the brain damage provoked by a stroke would be different depending on the source of dietary fat. To test this, male C57BL/6J mice were fed for 4 weeks with a standard low-fat diet (LFD), a high-fat diet (HFD) rich in saturated fatty acids (HFD-SFA), an HFD containing monounsaturated fatty acids (MUFAs) from olive oil (HFD-OO), or an HFD containing MUFAs from olive oil plus polyunsaturated fatty acids (PUFAs) docosahexaenoic acid/eicosapentaenoic acid (DHA/EPA) (HFD-OO-ω3). These mice were then subjected to transient middle cerebral artery occlusion (tMCAo). Behavioural tests and histological analyses were performed 24 and/or 48 h after tMCAo in order to elucidate the impact of these diets with different fatty acid profiles on the ischemic lesion and on neurological functions. Mice fed with HFD-OO-ω3 displayed better histological outcomes after cerebral ischemia than mice that received an HFD-SFA or LFD. Furthermore, PUFA- and MUFA-enriched diets improved the motor function and neurological performance of ischemic mice relative to those fed with an LFD or HFD-SFA. These findings support the use of DHA/EPA-omega-3-fatty acid supplementation and olive oil as dietary source of MUFAs in order to reduce the damage and protect the brain when a stroke occurs |
Identificador del proyecto | PI-0114-2016
PI-0024-2018 |
Cita | Bermúdez Pulgarín, B., Gonzálo Gobernado, R., Ayuso, M.I., Sansone, L., Bernal Jiménez, J.J., Ramos Herrero, V.D.,...,Abia González, M.d.R. (2019). Neuroprotective Effects of Diets Containing Olive Oil and DHA/EPA in a Mouse Model of Cerebral Ischemia. Nutrients, 11 (5), 1-17. |
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pubnutrients-11-01109.pdf | 3.479Mb | [PDF] | Ver/ | |