dc.creator | Díaz Moreno, Irene | es |
dc.creator | Velázquez Cruz, Alejandro | es |
dc.creator | Curran French, Seamus | es |
dc.creator | Díaz Quintana, Antonio Jesús | es |
dc.creator | Rosa Acosta, Miguel Ángel de la | es |
dc.date.accessioned | 2019-06-12T14:35:17Z | |
dc.date.available | 2019-06-12T14:35:17Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Díaz Moreno, I., Velázquez Cruz, A., Curran French, S., Díaz Quintana, A.J. y Rosa Acosta, M.Á.d.l. (2018). Nuclear cytochrome c – a mitochondrial visitor regulating damaged chromatin dynamics. FEBS Letters, 592 (2), 172-178. | |
dc.identifier.issn | 0014-5793 | es |
dc.identifier.issn | 1873-3468 | es |
dc.identifier.uri | https://hdl.handle.net/11441/87386 | |
dc.description.abstract | Over the past decade, evidence has emerged suggesting a broader role for cytochrome c (Cyt c) in programmed cell death. Recently, we demonstrated the ability of Cyt c to inhibit the nucleosome assembly activity of histone chaperones SET/template-activating factor Iβ and NAP1-related protein during DNA damage in humans and plants respectively. Here, we hypothesise a dual concentration-dependent function for nuclear Cyt c in response to DNA damage. We propose that low levels of highly cytotoxic DNA lesions – such as double-strand breaks – induce nuclear translocation of Cyt c, leading to the attenuation of nucleosome assembly and, thereby, increasing the time available for DNA repair. If DNA damage persists or is exacerbated, the nuclear Cyt c concentration would exceed a given threshold, causing the haem protein to block DNA remodelling altogether. | es |
dc.description.sponsorship | Ministerio de Economía, Industria y Competitividad BFU2015-71017/BMC | es |
dc.description.sponsorship | Junta de Andalucía BIO198 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Wiley-Blackwell | es |
dc.relation.ispartof | FEBS Letters, 592 (2), 172-178. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Chromatin remodelling | es |
dc.subject | Cytochrome c | es |
dc.subject | DNA damage response | es |
dc.subject | Histone chaperone | es |
dc.subject | Low-complexity acidic region | es |
dc.title | Nuclear cytochrome c – a mitochondrial visitor regulating damaged chromatin dynamics | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | es |
dc.relation.projectID | BFU2015-71017/BMC | es |
dc.relation.projectID | BIO198 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1002/1873-3468.12959 | es |
dc.identifier.doi | 10.1002/1873-3468.12959 | es |
idus.format.extent | 7 p. | es |
dc.journaltitle | FEBS Letters | es |
dc.publication.volumen | 592 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 172 | es |
dc.publication.endPage | 178 | es |