Article
DNA resection in eukaryotes: deciding how to fix the break
Author/s | Huertas Sánchez, Pablo |
Department | Universidad de Sevilla. Departamento de Genética |
Publication Date | 2010 |
Deposit Date | 2019-03-20 |
Published in |
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Abstract | DNA double-strand breaks are repaired by different mechanisms, including homologous
recombination and nonhomologous end-joining. DNA-end resection, the first step in
recombination, is a key step that contributes to the ... DNA double-strand breaks are repaired by different mechanisms, including homologous recombination and nonhomologous end-joining. DNA-end resection, the first step in recombination, is a key step that contributes to the choice of DSB repair. Resection, an evolutionarily conserved process that generates single-stranded DNA, is linked to checkpoint activation and is critical for survival. Failure to regulate and execute this process results in defective recombination and can contribute to human disease. Here, I review recent findings on the mechanisms of resection in eukaryotes, from yeast to vertebrates, provide insights into the regulatory strategies that control it, and highlight the consequences of both its impairment and its deregulation. |
Citation | Huertas Sánchez, P. (2010). DNA resection in eukaryotes: deciding how to fix the break. Nature Structural and Molecular Biology, 17 (1), 11-16. |
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