dc.creator | Hornillos, Valentín | es |
dc.creator | Carmona, José A. | es |
dc.creator | Ros Lao, Abel | es |
dc.creator | Iglesias Sigüenza, Francisco Javier | es |
dc.creator | López Serrano, Joaquín | es |
dc.creator | Fernández Fernández, Rosario Fátima | es |
dc.creator | Lassaletta, José M. | es |
dc.date.accessioned | 2019-02-01T08:26:39Z | |
dc.date.available | 2019-02-01T08:26:39Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Hornillos, V., Carmona, J.A., Ros Lao, A., Iglesias Sigüenza, F.J., López Serrano, J., Fernández Fernández, R.F. y Lassaletta, J.M. (2018). Dynamic Kinetic Resolution of Hetero biaryl Ketones by Zinc- Catalyzed Asymmetr ic Hydrosil ylation. Angewandte Chemie International Edition, 57, 3777-3781. | |
dc.identifier.issn | 1521-3773 | es |
dc.identifier.uri | https://hdl.handle.net/11441/82317 | |
dc.description.abstract | Adiastereo-
and
highly
enantioselective
dynamic
kinetic
resolution
(DKR)
of configurationally
labile
hetero-
biaryl
ketones
is described.
The
DKR
proceeds
by zinc-
catalyze
dhydrosilylation
of the carbonyl
group
,thus leading
to
secondary
alcohols
bearing
axial
and
central
chirality
.The
strategy
relies
on the labilization
of the stereogenic
axis
that
takes
place
thanks
to aLewis
acid–base
interaction
between
anitrogen
atom
in the heterocycle
and
the ketone
carbonyl
group
.The synthetic
utility
of the methodology
is demonstrated
through
stereospecific
transformations
into either
N,N-ligands
or appealing
axially
chiral,
bifunctional
thiourea
organocata-
lysts. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación (Grants CTQ2016-76908-C2-1-P, CTQ2016-76908-C2-2-P, contract RYC-2013-12585) | es |
dc.description.sponsorship | European FEDER Funds | es |
dc.description.sponsorship | Junta de Andalucía (Grant 2012/FQM 10787) | es |
dc.description.sponsorship | European Union - Marie Skłodowska-Curie (COFUND—Grant Agreement n 8 8 291780) | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.relation.ispartof | Angewandte Chemie International Edition, 57, 3777-3781. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Asymmetric catalysis | es |
dc.subject | Axial chirality | es |
dc.subject | Dynamic kinetic resolution | es |
dc.subject | Hydrosilylation | es |
dc.subject | Ligand design | es |
dc.title | Dynamic Kinetic Resolution of Hetero biaryl Ketones by Zinc- Catalyzed Asymmetr ic Hydrosil ylation | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Inorgánica | es |
dc.relation.projectID | CTQ2016-76908-C2-1-P | es |
dc.relation.projectID | CTQ2016-76908-C2-2-P | es |
dc.relation.projectID | RYC-2013-12585 | es |
dc.relation.projectID | 2012/FQM 10787 | es |
dc.relation.projectID | 291780 | es |
dc.date.embargoEndDate | 2019-03-07 | |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201713200 | es |
dc.identifier.doi | 10.1002/anie.201713200 | es |
idus.format.extent | 5 p. | es |
dc.journaltitle | Angewandte Chemie International Edition | es |
dc.publication.volumen | 57 | es |
dc.publication.initialPage | 3777 | es |
dc.publication.endPage | 3781 | es |
dc.description.awardwinning | Premio Anual Publicación Científica Destacada de la US. Facultad de Química | |