Artículo
Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
Autor/es | Silva, Sonia
Altmannova, Veronika Luke Glaser, Sarah Henriksen, Peter Gallina, Irene Yang, Xuejiao Choudhary, Chunaram Luke, Brian Krejci, Lumir Lisby, Michael |
Fecha de publicación | 2016 |
Fecha de depósito | 2019-01-17 |
Publicado en |
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Resumen | Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance
processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1
as a ... Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1 as a novel interactor of the Mph1 helicase in Saccharomyces cerevisiae. In vitro, Mte1 (Mph1-associated telomere maintenance protein 1) binds directly to DNA with a preference for branched molecules such as D loops and fork structures. In addition, Mte1 stimulates the helicase and fork regression activities of Mph1 while inhibiting the ability of Mph1 to dissociate recombination intermediates. Deletion of MTE1 reduces crossover recombination and suppresses the sensitivity of mph1Δ mutant cells to replication stress. Mph1 and Mte1 interdependently colocalize atDNAdamage-induced foci and dysfunctional telomeres, and MTE1 deletion results in elongated telomeres. Taken together, our data indicate that Mte1 plays a role in regulation of crossover recombination, response to replication stress, and telomere maintenance. |
Cita | Silva, S., Altmannova, V., Luke-Glaser, S., Henriksen, P., Gallina, I., Yang, X.,...,Lisby, M. (2016). Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Genes and Development, 30, 700-717. |
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