Article
Conditioned increase of locomotor activity induced by haloperidol
Author/s | Casa Rivas, Luis Gonzalo de La
![]() ![]() ![]() ![]() ![]() ![]() ![]() Cárcel Valle, Lucía Ruiz-Salas, Juan C. Vicente Holgado, Lucía Mena, Auxiliadora |
Department | Universidad de Sevilla. Departamento de Psicología Experimental |
Publication Date | 2018 |
Deposit Date | 2018-11-06 |
Published in |
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Abstract | Dopamine antagonist drugs have profound effects on locomotor activity. In particular, the administration of the D2 antagonist haloperidol produces a state that is similar to catalepsy. In order to confirm whether the ... Dopamine antagonist drugs have profound effects on locomotor activity. In particular, the administration of the D2 antagonist haloperidol produces a state that is similar to catalepsy. In order to confirm whether the modulation of the dopaminergic activity produced by haloperidol was repeatedly paired with the presence of distinctive contextual cues that served as a Conditioned Stimulus. Paradoxically, the results revealed a dose-dependent increase n locomotor activity following conditioning with dopamine antagonist (Experiments 1) that was susceptible of extinction when the conditioned stimulus was presented repeatedly by itself after conditioning (Experiment 2). These data are interpreted from an associative perspective, considering them as a result of a classical conditioning process. |
Funding agencies | Ministerio de Economia, Industria y Competitividad (MINECO). España |
Project ID. | PSI2015-64 965-P
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Citation | Casa Rivas, L.G.d.L., Cárcel Valle, L., Ruiz-Salas, J.C., Vicente Holgado, L. y Mena, A. (2018). Conditioned increase of locomotor activity induced by haloperidol. PLOS ONE, 13 (10) |
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