Artículo
Stereoselective enzymatic reduction of 1,4-diaryl-1,4-diones to the corresponding diols employing alcohol dehydrogenases
Autor/es | Mourelle Insua, Ángela
Gonzalo Calvo, Gonzalo de Lavandera, Iván Gotor Fernández, Vicente |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2018 |
Fecha de depósito | 2018-05-22 |
Publicado en |
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Resumen | Due to the steric hindrance of the starting prochiral ketones, the preparation of chiral
1,4-diaryl-1,4-diols through the asymmetric hydrogen transfer reaction has been mainly restricted
to the use of metal-based catalysts, ... Due to the steric hindrance of the starting prochiral ketones, the preparation of chiral 1,4-diaryl-1,4-diols through the asymmetric hydrogen transfer reaction has been mainly restricted to the use of metal-based catalysts, oxazaborolidines, or organocatalysts. Herein, we demonstrated the versatility of oxidoreductases, finding overexpressed alcohol dehydrogenase from Ralstonia sp. (E. coli/RasADH) as the most active and stereoselective biocatalyst. Thus, the preparation of a set of 1,4-diaryl-1,4-diols bearing different pattern substitutions in the aromatic ring was achieved with complete diastereo- and enantioselectivity under mild reaction conditions. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España |
Identificador del proyecto | CTQ2016-75752-R |
Cita | Mourelle Insua, Á., Gonzalo Calvo, G.d., Lavandera, I. y Gotor Fernández, V. (2018). Stereoselective enzymatic reduction of 1,4-diaryl-1,4-diones to the corresponding diols employing alcohol dehydrogenases. Catalysts, 8 (4), 150. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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catalysts-08-00150.pdf | 1.194Mb | [PDF] | Ver/ | |