Artículo
Bioavailability of the ferulic acid-derived phenolic compounds of a rice bran enzymatic extract and their activity against superoxide production
Autor/es | Pérez Ternero, Cristina
Maciá, Alba Álvarez de Sotomayor Paz, María Parrado Rubio, Juan Motilva, María José Herrera González, María Dolores |
Departamento | Universidad de Sevilla. Departamento de Farmacología Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular |
Fecha de publicación | 2017 |
Fecha de depósito | 2018-01-23 |
Publicado en |
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Resumen | ice bran is an exceptional source of such antioxidant molecules as γ-oryzanol and ferulic acid, but their bioavailability and metabolism within this matrix remain unknown. The aims of this work were to describe the oral ... ice bran is an exceptional source of such antioxidant molecules as γ-oryzanol and ferulic acid, but their bioavailability and metabolism within this matrix remain unknown. The aims of this work were to describe the oral bioavailability and metabolic pathways of the ferulic acid-derived phenolic compounds contained in a rice bran enzymatic extract (RBEE), and to determine its effect on NADPH oxidase activity. Wistar rats were administered with RBEE and sacrificed at different times over a period of 24 h to obtain plasma. An additional group was used for collection of urine and faeces over a period of 48 h. The phenolic metabolites were determined by ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS), and plasma pharmacokinetic parameters were calculated. In parallel, aortic rings were incubated in the plasma of rats sacrificed 30 min after RBEE gavage, or in the presence of RBEE, ferulic acid or γ-oryzanol. Endothelin-1-induced superoxide production was recorded by lucigenin-enhanced luminescence. Twenty-five ferulic acid metabolites showing biphasic behaviour were found in the plasma, most of which were found in the urine as well, while in the faeces, colonic metabolism led to simpler phenolic compounds. Superoxide production was abrogated by phenolic compound-enriched plasma and by RBEE and ferulic acid, thus showing the biological potential of RBEE as a nutraceutical ingredient. |
Cita | Pérez Ternero, C., Maciá, A., Álvarez de Sotomayor Paz, M., Parrado Rubio, J., Motilva, M.J. y Herrera González, M.D. (2017). Bioavailability of the ferulic acid-derived phenolic compounds of a rice bran enzymatic extract and their activity against superoxide production. Food and Function, 8 (6), 2165-2174. |
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C Perez Food Function 2017.pdf | 4.140Mb | [PDF] | Ver/ | |