dc.creator | López-Rojas, Rafael | es |
dc.creator | Domínguez-Herrera, J. | es |
dc.creator | Mcconnell, Michael | es |
dc.creator | Docobo Pérez, Fernando | es |
dc.creator | Smani, Younes | es |
dc.creator | Pachón Díaz, Jerónimo | es |
dc.date.accessioned | 2017-11-22T18:23:29Z | |
dc.date.available | 2017-11-22T18:23:29Z | |
dc.date.issued | 2011-01-07 | |
dc.identifier.citation | López Rojas, R., Domínguez-Herrera, J., Mcconnell, M., Dacobo Pérez, F., Smani, Y. y Pachón Díaz, J. (2011). Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii. The Journal of Infectious Diseases, 203 (4), 545-548. | |
dc.identifier.issn | 0022-1899 (impreso) | es |
dc.identifier.issn | 1537-6613 (electrónico) | es |
dc.identifier.uri | http://hdl.handle.net/11441/66493 | |
dc.description.abstract | Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virulence, both in terms of mortality (0% lethal dose, 6.9 vs 4.9 log colony-forming units) and survival in a mouse model of peritoneal sepsis. These results may explain the low incidence and dissemination of colistin resistance in A. baumannii in clinical settings. | es |
dc.description.sponsorship | REIPI RD06/0008 | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación y Comunidad de Madrid COMBACT S-BIO-0260/2006 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Oxford University Press | es |
dc.relation.ispartof | The Journal of Infectious Diseases, 203 (4), 545-548. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Acinetobacter infections | es |
dc.subject | Acinetobacter baumannii | es |
dc.subject | Animals | es |
dc.subject | Anti-bacterial agents | es |
dc.subject | Bacterial proteins | es |
dc.subject | Colistin | es |
dc.subject | Peritonitis | es |
dc.subject | Sepsis | es |
dc.title | Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | RD06/0008 | es |
dc.relation.projectID | COMBACT S-BIO-0260/2006 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1093/infdis/jiq086 | es |
dc.identifier.doi | 10.1093/infdis/jiq086 | es |
idus.format.extent | 4 p. | es |
dc.journaltitle | The Journal of Infectious Diseases | es |
dc.publication.volumen | 203 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 545 | es |
dc.publication.endPage | 548 | es |
dc.identifier.sisius | 20126064 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | |