Artículo
Intravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbits
Autor/es | López Cortés, Luis Fernando
Ruiz Valderas, Rosa Lucero Muñoz, María Jesús Cordero Matia, María Elisa Pastor Ramos, M. T. Márquez, Javier |
Departamento | Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2000-03-01 |
Fecha de depósito | 2017-09-28 |
Publicado en |
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Resumen | Retinal, vitreous humor, brain, and cerebrospinal fluid (CSF) foscarnet levels were measured by high-performance liquid chromatography after administration of an intravenous dose of 120 mg/kg of body weight to 32 pigmented ... Retinal, vitreous humor, brain, and cerebrospinal fluid (CSF) foscarnet levels were measured by high-performance liquid chromatography after administration of an intravenous dose of 120 mg/kg of body weight to 32 pigmented rabbits. A pharmacokinetic analysis was done using a two- compartment model. The penetration ratios, defined as ratios of retinal, vitreous humor, brain, and CSF areas under the concentration-time curve from 0 to 2 h were 110% ± 1%, 12.3% ± 0.7%, 118% ± 1%, and 20.2% ± 2.2%, respectively. These results suggest a good penetration of foscarnet into the retinal and brain tissues, reaching higher concentrations than those estimated from vitreous humor and CSF levels. |
Agencias financiadoras | Comisión Interministerial de Ciencia y Tecnología (CICYT). España Junta de Andalucía |
Identificador del proyecto | SAF97-0012
64/96 |
Cita | López Cortés, L.F., Ruiz Valderas, R., Lucero Muñoz, M.J., Cordero, E., Pastor Ramos, M.T. y Márquez, J. (2000). Intravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbits. Antimicrobial Agents and Chemotherapy, 44 (3), 756-759. |
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