Artículo
Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets
Autor/es | Díaz Moreno, Irene
Hollingworth, David Kelly, Geoff Martin, Stephen García Mayoral, María Flor |
Fecha de publicación | 2010 |
Fecha de depósito | 2017-08-31 |
Publicado en |
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Resumen | KSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular proliferation and inflammatory response factors. The selectivity of this mRNA degradation ... KSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular proliferation and inflammatory response factors. The selectivity of this mRNA degradation mechanism relies on KSRP recognition of AU-rich elements in the mRNA 3′UTR, that is mediated by KSRP’s KH domains. Our structural analysis shows that the inter-domain linker orients the two central KH domains of KSRP—and their RNA-binding surfaces—creating a two-domain unit. We also show that this inter-domain arrangement is important to the interaction with KSRP’s RNA targets. |
Cita | Díaz Moreno, I., Hollingworth, a., Kelly, G., Martin, S. y García Mayoral, M.F. (2010). Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets. Nucleic Acids Research, 38 (15), 5193-5205. |
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