Artículo
Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: Mura confers clinical resistance at low fitness cost
Autor/es | Cauce, Alejandro
Briales, Alejandra Rodríguez Rojas, Alexandro Costas, Coloma Pascual Hernández, Álvaro Blázquez, Jesús |
Departamento | Universidad de Sevilla. Departamento de Microbiología |
Fecha de publicación | 2012-05-01 |
Fecha de depósito | 2017-07-27 |
Publicado en |
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Resumen | To determine whether the overexpression of chromosomal genes can confer fosfomycin resistance, genomewide screening of a complete set of 5,272 plasmid-expressed open reading frames of Escherichia coli (ASKA collection) was ... To determine whether the overexpression of chromosomal genes can confer fosfomycin resistance, genomewide screening of a complete set of 5,272 plasmid-expressed open reading frames of Escherichia coli (ASKA collection) was performed. Major results are that (i) no clinical level of resistance is achieved by overexpressing chromosomal genes, except murA; (ii) this level is reached at a low fitness cost; and (iii) this cost is much lower than that imposed by other mutations conferring fosfomycin resistance. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España |
Identificador del proyecto | PI10/00105
REIPI RD06/0008 |
Cita | Cauce, A., Briales, A., Rodríguez Rojas, A., Costas, C., Pascual Hernández, Á. y Blázquez, J. (2012). Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: Mura confers clinical resistance at low fitness cost. Antimicrobial Agents and Chemotherapy, 56 (5), 2767-2769. |
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