Artículo
Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma
Autor/es | Cordero Morales, Mario David
Alcocer-Gómez, Elísabet Cano García, Francisco Javier Miguel Rodríguez, Manuel de Carrion Rodriguez, Angel Navas Lloret, Plácido Sánchez Alcázar, José Antonio |
Departamento | Universidad de Sevilla. Departamento de Personalidad, Evaluación y Tratamiento Psicológicos Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica |
Fecha de publicación | 2011 |
Fecha de depósito | 2017-02-15 |
Publicado en |
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Resumen | Background: We examined lipid peroxidation (LPO) in blood mononuclear cells (BMCs) and plasma, as a marker of oxidative damage, and its association to clinical symptoms in Fibromyalgia (FM) patients. Methods: We conducted ... Background: We examined lipid peroxidation (LPO) in blood mononuclear cells (BMCs) and plasma, as a marker of oxidative damage, and its association to clinical symptoms in Fibromyalgia (FM) patients. Methods: We conducted a case–control and correlational study comparing 65 patients and 45 healthy controls. Clinical parameters were evaluated using the Fibromyalgia Impact Questionnaire (FIQ), visual analogues scales (VAS), and the Beck Depression Inventory (BDI). Oxidative stress was determined by measuring LPO in BMCs and plasma. Results: We found increased LPO levels in BMCs and plasma from FM patients as compared to normal control (P<0.001). A significant correlation between LPO in BMCs and clinical parameters was observed (r = 0.584, P<0.001 for VAS; r = 0.823, P<0.001 for FIQ total score; and r = 0.875, P<0.01 for depression in the BDI). We also found a positive correlation between LPO in plasma and clinical symptoms (r = 0.452, P<0.001 for VAS; r = 0.578, P<0.001 for FIQ total score; and r = 0.579, P<0.001 for depression in the BDI). Partial correlation analysis controlling for age and BMI, and sex, showed that both LPO in cells and plasma were independently associated to clinical symptoms. However, LPO in cells, but not LPO in plasma, was independently associated to clinical symptoms when controlling for depression (BDI scores). Discussion: The results of this study suggest a role for oxidative stress in the pathophysiology of fibromyalgia and that LPO in BMCs rather than LPO in plasma is better associated to clinical symptoms in FM. |
Agencias financiadoras | Ministerio de Sanidad. España Federación Andaluza de Fibromialgia y Fatiga Crónica |
Identificador del proyecto | FIS PI080500
FIS EC08/00076 |
Cita | Cordero Morales, M.D., Alcocer-Gómez, E., Cano García, F.J., Miguel Rodríguez, M.d., Carrion Rodriguez, A., Navas Lloret, P. y Sánchez Alcázar, J.A. (2011). Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma. Plos One, 6 (10), 1-6. |
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